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Titolo:
Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B
Autore:
Xu, WD; Smith-Franklin, BA; Li, PL; Wood, C; He, J; Du, QJ; Bhat, GJ; Kankasa, C; Katinger, H; Cavacini, LA; Posner, MR; Burton, DR; Chou, TC; Ruprecht, RM;
Indirizzi:
Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA DanaFarber Canc Inst Boston MA USA 02115 ol & AIDS, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA USA Harvard Univ Boston MA USA rvard Univ, Sch Med, Dept Med, Boston, MA USA Univ Nebraska, Sch Biol Sci, Lincoln, NE USA Univ Nebraska Lincoln NE USA niv Nebraska, Sch Biol Sci, Lincoln, NE USA Univ Teaching Hosp, Lusaka, Zambia Univ Teaching Hosp Lusaka ZambiaUniv Teaching Hosp, Lusaka, Zambia Inst Appl Microbiol, A-1190 Vienna, Austria Inst Appl Microbiol Vienna Austria A-1190 robiol, A-1190 Vienna, Austria Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 r, Boston, MA 02215 USA Scripps Clin & Res Inst, Dept Immunol & Mol Biol, La Jolla, CA USA ScrippsClin & Res Inst La Jolla CA USA nol & Mol Biol, La Jolla, CA USA Mem Sloan Kettering Canc Ctr, Biochem Pharmacol Lab, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Preclin Pharmacol Core Facil, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
JOURNAL OF HUMAN VIROLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 55 - 61
SICI:
1090-9508(200103/04)4:2<55:PNOPHI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-ANALYSIS; DEVELOPING-WORLD; HIV TYPE-1; SUBTYPE-C; TRANSMISSION; PREVENTION; INFECTION; SEROTYPES; GENERATION; PROTECTION;
Keywords:
HIV-1 clade C; neutralization; human neutralizing monoclonal antibodies; passive immunization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ruprecht, RM Dana Farber Canc Inst, Dept Canc Immunol & AIDS, 44 Binney St, Boston, MA 02115 USA Dana Farber Canc Inst 44 Binney St Boston MA USA 02115 15 USA
Citazione:
W.D. Xu et al., "Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B", J HUMAN VIR, 4(2), 2001, pp. 55-61

Abstract

Objectives: We investigated the ability of several human neutralizing monoclonal antibodies (mAbs), originally raised against human immunodeficiency virus (HIV) clade B isolates, to neutralize primary clade C isolates as single agents and in combination.tudy Design/Methods: HIV clade C isolates from five different countries were tested for susceptibility to neutralization by anti-clade B mAbs in human peripheral blood mononuclear cells. Monoclonal antibody combinations wereevaluated for possible synergy. Results: All 20 primary HIV clade C isolates could be neutralized 97.5% to100% by a quadruple combination of mAbs IgG1b12. 2G12, 2F5, and 4E10. These mAbs recognized conserved epitopes and were highly synergistic, resultingin strong cross-clade neutralization. Conclusions: In our previous experiment, a synergistic combination of human neutralizing mABs protected all macaque neonates against oral challenge with a simian-human immunodeficiency virus encoding HIV env. Together, our data suggest that passive immunization with currently available anticlade B mAbs could play a role in preventing HIV clade C transmission through breastfeeding.

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Documento generato il 04/04/20 alle ore 12:02:25