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Titolo:
Anticonvulsant properties of the methanolic extract of Cyperus articulatus(Cyperaceae)
Autore:
Bum, EN; Schmutz, M; Meyer, C; Rakotonirina, A; Bopelet, M; Portet, C; Jeker, A; Rakotonirina, SV; Olpe, HR; Herrling, P;
Indirizzi:
Univ Ngaoundere, Fac Sci, Dept Biol Sci, Ngaoundere, Cameroon Univ Ngaoundere Ngaoundere Cameroon Dept Biol Sci, Ngaoundere, Cameroon Novartis Pharma Ltd, CH-4002 Basel, Switzerland Novartis Pharma Ltd Basel Switzerland CH-4002 CH-4002 Basel, Switzerland Univ Yaounde, Fac Sci, Dept Biol & Physiol Anim, Yaounde, Cameroon Univ Yaounde Yaounde Cameroon pt Biol & Physiol Anim, Yaounde, Cameroon
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2, volume: 76, anno: 2001,
pagine: 145 - 150
SICI:
0378-8741(200107)76:2<145:APOTME>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIEPILEPTIC DRUGS; MODELS;
Keywords:
epilepsy; anticonvulsant; methanolic extract; seizures; Cyperus articulatus L;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Bum, EN Univ Ngaoundere, Fac Sci, Dept Biol Sci, BP 454, Ngaoundere, Cameroon Univ Ngaoundere BP 454 Ngaoundere Cameroon Ngaoundere, Cameroon
Citazione:
E.N. Bum et al., "Anticonvulsant properties of the methanolic extract of Cyperus articulatus(Cyperaceae)", J ETHNOPHAR, 76(2), 2001, pp. 145-150

Abstract

The methanolic extract of rhizomes of Cyperus articulatus, a plant used intraditional medicine in Africa and Latin America for many diseases, possesses anticonvulsant activity in mice. This extract protected mice against maximal electroshock (MES)- and pentylenetetrazol (PTZ)-induced seizures. It also delayed the onset of seizures induced by isonicotinic acid hydrazide and strongly antagonized N-methyl-D-aspartate-induced turning behavior. The ED,, for protection against seizures was 306 (154-541) mg/kg intraperitoneally (i.p.) for the PTZ test and 1005 (797-1200) mg/kg i.p. for the MES test. The ED,, of methanolic extract against N-methyl-D-aspartate-induced turning behavior was 875 (623 - 1123) mg/kg i.p. C. articulatus L. methanolic extract protected 54% of mice from seizures induced by strychnine at the doseof 1000 mg/kg i.p. but had no or a moderate effect only against picrotoxin- or bicuculline-induced seizures. With these effects, the rhizome of C. articulatus L. possesses anticonvulsant properties in animals that might explain its use as a traditional medicine for epilepsy in Africa. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:17:25