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Titolo:
A SURVEY OF IN-SITU SARCOMERE EXTENSION IN MOUSE SKELETAL-MUSCLE
Autore:
GOULDING D; BULLARD B; GAUTEL M;
Indirizzi:
EUROPEAN MOL BIOL LAB,STRUCT BIOL DIV,POSTFACH 102209 D-69012 HEIDELBERG GERMANY EUROPEAN MOL BIOL LAB,STRUCT BIOL DIV D-69012 HEIDELBERG GERMANY
Titolo Testata:
Journal of muscle research and cell motility
fascicolo: 4, volume: 18, anno: 1997,
pagine: 465 - 472
SICI:
0142-4319(1997)18:4<465:ASOISE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; IMMUNOELECTRON MICROSCOPY; VERTEBRATE SKELETAL; TENSION DEVELOPMENT; TITIN FILAMENTS; PASSIVE TENSION; RESTING TENSION; STRIATED-MUSCLE; ELASTICITY; LENGTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D. Goulding et al., "A SURVEY OF IN-SITU SARCOMERE EXTENSION IN MOUSE SKELETAL-MUSCLE", Journal of muscle research and cell motility, 18(4), 1997, pp. 465-472

Abstract

The giant molecule titin/connectin was demonstrated to connect the ends of thick filaments with the Z-disks and thus to provide an elastic connection that seems to be responsible for passive tension in striated muscle. To investigate the physiological limits of I-band titin extension in skeletal muscle, we have measured sarcomere lengths of a number of mouse postural and clonal muscles ii? situ under the constraintsimposed by the skeletal, ligamentous and tendinous components of the motile apparatus. These values now give upper limits for the extensionof the I-band and therefore for the maximal degree of titin extensionunder physiological constraints. We find that I-band extension in allmuscles investigated does not exceed a factor of approximate to 2.5 in situ, which is well below values obtainable in isolated fibre preparations. Approach to the yield-point is therefore prevented by extramuscular mechanisms. Sarcomere lengths near the tendinous junction and within the muscle are virtually identical in extended muscle, suggestingthat a major function of titin in intact muscle is to ensure uniform sarcomere lengths over the entire muscle length and thus to prevent localized myofibril overstretch during isometric contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 07:00:41