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Titolo:
Mechanisms of action in the treatment of anxiety
Autore:
Shelton, RC; Brown, LL;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN 37121 USA Vanderbilt Univ Nashville TN USA 37121 Psychiat, Nashville, TN 37121 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 62, anno: 2001, supplemento:, 12
pagine: 10 - 15
SICI:
0160-6689(2001)62:<10:MOAITT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; STRIATAL DOPAMINE RELEASE; VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; GENERALIZED ANXIETY; RECEPTOR SUBTYPES; IN-VIVO; TRIPARTITE MODEL; STRESS RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Shelton, RC Vanderbilt Univ, Med Ctr, Dept Psychiat, 1500 21 Ave S,Suite 2200, Nashville, TN 37121 USA Vanderbilt Univ 1500 21 Ave S,Suite 2200 Nashville TN USA 37121
Citazione:
R.C. Shelton e L.L. Brown, "Mechanisms of action in the treatment of anxiety", J CLIN PSY, 62, 2001, pp. 10-15

Abstract

Anxiety and depressive disorders share many features, suggesting a common set of physiologic substrates. Recent research has indicated that mood can be categorized into 3 components by factor analysis: (1) somatic anxiety (afactor relatively specific to panic disorder), (2) anhedonic depression (which includes symptoms related to motivation and enjoyment and found to be specific to depression), and (3) general distress (a factor that cuts across all depressive and anxiety disorders studied). Antidepressant drugs, particularly serotonin reuptake inhibitors and serotonin receptor modulators, are effective for a wide variety of anxiety and depressive disorders. The impact on both anxiety and depression may be a result of an effect on a common set of physiologic targets relevant to the general distress dimension. Ata cellular level, the antidepressants target components of the stress-adaptation system in brain, which may explain these common effects. On the other hand, there appear to be differences in the relative impact of serotonergic and noradrenergic drugs on the spectrum of distress and motivational symptoms. Basic research and clinical research suggest that serotonergic agents may be preferentially effective for symptoms of general distress, whereascatecholaminergic agents may target anhedonic depression symptoms.

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Documento generato il 27/01/20 alle ore 07:19:45