Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: A reanalysis using drug-placebo and drug-drug response curve methodology
Autore:
Faraone, SV; Pliszka, SR; Olvera, RL; Skolnik, R; Biederman, J;
Indirizzi:
Massachusetts Gen Hosp, Child Psychiat Serv, Pediat Psychopharmacol Unit ACC 725, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ACC 725, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Epidemiol & Genet, Boston, MA 02115 USA Univ Texas, Hlth Sci Ctr, San Antonio, TX USA Univ Texas San Antonio TX USA v Texas, Hlth Sci Ctr, San Antonio, TX USA
Titolo Testata:
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 171 - 180
SICI:
1044-5463(200122)11:2<171:EOAAMI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DSM-III-R; DEFICIT/HYPERACTIVITY DISORDER; AUTISTIC DISORDER; CHILDREN; TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Faraone, SV Massachusetts Gen Hosp, Child Psychiat Serv, Pediat Psychopharmacol Unit ACC 725, 15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St Boston MA USA 02114 4 USA
Citazione:
S.V. Faraone et al., "Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: A reanalysis using drug-placebo and drug-drug response curve methodology", J CH AD PSY, 11(2), 2001, pp. 171-180

Abstract

Because methylphenidate (MPH) is currently the most widely prescribed medication for attention deficit hyperactivity disorder (ADHD), several studieshave used this as the touchstone for evaluating the efficacy of a newer stimulant, Adderall. In a parallel-groups study of MPH (n = 20), Adderall (n = 20), and placebo (n = 18), Pliszka et al. (2000) reported that both medications were superior to placebo in improving parent, teacher, and clinicianratings of ADHD and associated behaviors. Compared with MPH, Adderall led to significantly more improvements in teacher and clinician ratings. The present study extends these results by addressing the issue of clinical significance using drug-placebo and drug-drug response curve analyses of the same data. The goal of this method is to answer the following questions about drug-placebo or drug-drug differences: Is the effect clinically meaningful? What does the effect tell us about individual responses? Is the effect dueto symptom improvement, the prevention of worsening, or both? Our results show that the efficacy of Adderall to improve functioning is seen throughout the full range of improvement scores. In contrast, MPH showed a substantial effect for "mildly" and "much improved" but not for "very much improved. " Our analyses also show that both Adderall and MPH prevent worsening of symptoms. They further suggest that, compared with the Conners Teacher RatingScale, the Clinical Global Impressions scale may be more sensitive to improvements at the "well end" of the spectrum of functioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:43:05