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Titolo:
Alteration of Bcl-2 expression in the nigrostriatal system after kainate injection with or without melatonin co-treatment
Autore:
Chuang, JI; Chen, ST; Chang, YH; Jen, LS;
Indirizzi:
Natl Cheng Kung Univ, Coll Med, Dept Anat, Tainan 70101, Taiwan Natl ChengKung Univ Tainan Taiwan 70101 Dept Anat, Tainan 70101, Taiwan Natl Cheng Kung Univ, Dept Physiol, Tainan 701, Taiwan Natl Cheng Kung Univ Tainan Taiwan 701 Dept Physiol, Tainan 701, Taiwan Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Neuroinflammat,Div Neurosci & Physiol Med, London, England Univ London Imperial Coll Sci Technol & Med London England don, England
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 215 - 223
SICI:
0891-0618(200105)21:3<215:AOBEIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; BETA-AMYLOID PRECURSOR; INDUCED CELL-DEATH; KAINIC ACID; RAT-BRAIN; PROTOONCOGENE PROTEINS; INDUCED APOPTOSIS; NEURONAL DEATH; X EXPRESSION; CYTOCHROME-C;
Keywords:
Bcl-2; melatonin; kainate; neuroprotection; nigrostriatal pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, ST Natl Cheng Kung Univ, Coll Med, Dept Anat, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 , Tainan 70101, Taiwan
Citazione:
J.I. Chuang et al., "Alteration of Bcl-2 expression in the nigrostriatal system after kainate injection with or without melatonin co-treatment", J CHEM NEUR, 21(3), 2001, pp. 215-223

Abstract

In order to understand further the role of the anti-apoptotic Bcl-2 proto-oncogene protein in excitotoxin-induced brain injury and possible interaction between Bcl-2 and the antioxidant melatonin, the expression of Bcl-2 in various brain parts was studied after intrastriatal injection of kainate (KA, 2.5 nmol) with or without co-treatment of melatonin (10 mg/kg, intraperitoneally (i.p.)). Three days after unilateral injection of KA to the striatum in the rat, a dramatic direct cytotoxic effect was observed, as indicated an expression of Bcl-2 immunoreactivity in. TUNEL- and OX-42-positive cells in the KA-injected striatum and traumatized cortical region. A less severe detrimental effect was also observed in the ipsilateral substantia nigraand peritraumatic cortex, as reflected by an upregulation of Bcl-2-immunostained neurons. Surprisingly, a reduction in Bcl-2-immunoreactive neurons that was accompanied by a less severe loss of tyrosine hydroxylase-immunoreactive neurons in the nigrostriatal pathway was observed after co-treatment with melatonin. Western blot analysis confirmed that Bcl-2 expression is elevated in striatum and cortex on the lesioned side, and that its expressionwas attenuated substantially after systemic administration of melatonin. The results showing an upregulation of Bcl-2 in nigral neurons and reactive microglia after KA lesion are consistent with the view that Bcl-2 is protective in function in the central nervous system. (C) 2001 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:13:11