Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analysis of vasodilator responses to novel nitric oxide donors in the hindquarters vascular bed of the cat
Autore:
Bivalacqua, TJ; Champion, HC; De Witt, BJ; Saavedra, JE; Hrabie, JA; Keefer, LK; Kadowitz, PJ;
Indirizzi:
Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 Pharmacol, New Orleans, LA 70112 USA NCI, Frederick Canc Res & Dev Ctr, Comparat Carcinogenesis Lab, Frederick,MD USA NCI Frederick MD USA Ctr, Comparat Carcinogenesis Lab, Frederick,MD USA SAIC Frederick, Frederick, MD USA SAIC Frederick Frederick MD USASAIC Frederick, Frederick, MD USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 1, volume: 38, anno: 2001,
pagine: 120 - 129
SICI:
0160-2446(200107)38:1<120:AOVRTN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED BIOLOGICAL RELEASE; SMOOTH-MUSCLE RELAXATION; RELAXING FACTOR; COMPLEXES; MECHANISM; NUCLEOPHILES; PHARMACOLOGY; NONOATES; ARTERY; AGENTS;
Keywords:
diazeniumdiolate; feline; NO donors; regional vascular bed;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kadowitz, PJ Tulane Univ, Sch Med, Dept Pharmacol, 1430 Tulane Ave,SL83, New Orleans, LA 70112 USA Tulane Univ 1430 Tulane Ave,SL83 New Orleans LA USA 70112 USA
Citazione:
T.J. Bivalacqua et al., "Analysis of vasodilator responses to novel nitric oxide donors in the hindquarters vascular bed of the cat", J CARDIO PH, 38(1), 2001, pp. 120-129

Abstract

Controlled release of nitric oxide (NO.) may be useful in the treatment ofa variety of vascular disorders. NO. donors of the diazeniumdiolate familywith different rates of spontaneous NO. release have been synthesized. In the current study responses to seven diazeniurndiolate NO. donors (DEA/NO.,DETA/NO., OXI/NO., PIPERAZI/NO., PROLT/NO., SPER/NO., and SULFI/NO.) were investigated in the hindquarters vascular bed of the cat. Intravenous injections of all NO. donors caused dose-dependent decreases in systemic arterial pressure and the rank order of potency was SNP > DEA/NO. > PIPERAZI/NO. >SPER/NO. > PROLI/NO. > OXI/NO., Injections of all NO. donors into the hindlimb perfusion circuit caused dose-related decreases in hindquarters perfusion pressure that were similar to the order of potency in decreasing systemic arterial pressure. The rank order of the time required for the response to return to 50% of the maximal decrease in pressure (T-1/2) and total duration of action of the NO. donors was SPER/NO. > PIPERAZI/NO. > DEA/NO. > OXVNO. > DETA/NO. > PROLI/NO. > SULFI/NO.. After treatment with the NO. synthase inhibitor, N-omega-nitro-L-arginine methyl ester (100 mg/kg, i.v.), hindlimb vasodilator responses to the NO. donors were not significantly different, but vasodilator responses to acetylcholine were significantly reduced. After treatment with zaprinast (2 mg/kg, i.v.), a type V cyclic 3 ', 5 ' -guanosine monophosphate-specific phosphodiesterase inhibitor, the duration of vasodilator responses to the NO. donors, as measured by T-1/2, was increased significantly, whereas the duration of the response to the beta (2)-adrenergic receptor agonist albuterol was unchanged. These data suggest that diazeniumdiolate NO. donors are endothelium-independent, directly stimulatesoluble guanylate cyclase, and decrease vascular resistance by increasing cyclic 3 ', 5 ' -guanosine monophosphate levels in the hindquarters vascular bed of the cat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:37:09