Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery
Autore:
Feneck, RO; Sherry, KM; Withington, S; Oduro-Dominah, A;
Indirizzi:
St Thomas Hosp, Dept Anesthesia, London SE1 7EH, England St Thomas Hosp London England SE1 7EH nesthesia, London SE1 7EH, England London Chest Hosp, Dept Anesthesia, London E2 9JX, England London Chest Hosp London England E2 9JX esthesia, London E2 9JX, England No Gen Hosp, Dept Anesthesia, Sheffield S5 7AU, S Yorkshire, England No Gen Hosp Sheffield S Yorkshire England S5 7AU AU, S Yorkshire, England Royal London Hosp, Dept Anesthesia, London E1 1BB, England Royal London Hosp London England E1 1BB esthesia, London E1 1BB, England Papworth Hosp, Dept Anesthesia, Cambridge CB3 8RE, England Papworth Hosp Cambridge England CB3 8RE esia, Cambridge CB3 8RE, England Freeman Rd Hosp, Dept Anesthesia, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England Freeman Rd Hosp Newcastle Upon Tyne Tyne & Wear England NE7 7DN , England
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 3, volume: 15, anno: 2001,
pagine: 306 - 315
SICI:
1053-0770(200106)15:3<306:COTHEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; LEFT-VENTRICULAR FUNCTION; CARDIOPULMONARY BYPASS; PHOSPHODIESTERASE INHIBITORS; INTRAVENOUS MILRINONE; BLOOD-FLOW; AMRINONE; EMERGENCE; DOPAMINE; ARTERY;
Keywords:
milrinone; dobutamine; cardiac surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Feneck, RO St Thomas Hosp, Dept Anesthesia, Lambeth Palace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH ngland
Citazione:
R.O. Feneck et al., "Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery", J CARDIOTHO, 15(3), 2001, pp. 306-315

Abstract

Objective: To compare the hemodynamic effects, efficacy, and safety of intravenous milrinone (M), 50 mug/kg during 10 minutes followed by 0.5 mug/kg/min, with intravenous dobutamine (D), 10 to 20 mug/kg/min, in patients withlow cardiac output after cardiac surgery. Design: Randomized, open label, multicenter study. Setting: Cardiothoracic surgery departments, operating rooms, and intensive care units in 6 university hospitals. Participants: Patients (n = 120; 60 per group) after elective cardiac surgery. Interventions: None. Measurements and Main Results: Analysis compared the hemodynamics at baseline and the percentage change from baseline during 4 hours of the drug infusion. The incidence of adverse events was recorded. Both groups had low mean (+/- SEM) cardiac indices (M, 1.6([0.03] L/min/m(2); D, 1.7 [0.03] L/min/m(2)) in association with adequate mean pulmonary capillary wedge pressures(M, 13.7 [1.3] mmHg; D, 12.7 [1.9] mmHg) at baseline. Group NI had significantly higher systemic arterial pressures and systemic Vascular resistancescompared with group D; otherwise, the hemodynamics in both groups were comparable. During the study, hemodynamic responses included the following: group D had greater increases in cardiac index (at 1 hour, D = 55%, M = 36%; p < 0.01), heart rate (at 1 hour, D = 35%, M = 10%; p < 0.001), arterial pressures (mean arterial pressure at 1 hour, D = 31%, M = 7%; p < 0.001), andleft ventricular stroke work index (at 1 hour, D = 75%, M = 45%; p < 0.05). Group M had greater decreases in mean pulmonary capillary wedge pressure (at 1 hour, D = -3%, M = -14%; p < 0.05). Comparisons of adverse events showed that dobutamine was associated with a higher incidence of hypertension (D = 40%, M = 13%; p < 0.02) and change of rhythm from sinus to atrial fibrillation (D = 18%, M = 5%; p < 0.04). Milrinone was associated with a higher incidence of sinus bradycardia (D = 2%, M = 13%; p < 0.03). Conclusions: Milrinone and dobutamine are appropriate and comparable for the pharmacologic treatment of the low-output syndrome after cardiopulmonarybypass. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:44:42