Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanical alternans in patients with chronic heart failure
Autore:
Kodama, M; Kato, K; Hirono, S; Okura, Y; Hanawa, H; Ito, M; Fuse, K; Shiono, T; Watanabe, K; Aizawa, Y;
Indirizzi:
Niigata Univ, Sch Med, Dept Internal Med 1, Niigata 9518510, Japan NiigataUniv Niigata Japan 9518510 nternal Med 1, Niigata 9518510, Japan Niigata Coll Pharm, Dept Clin Pharmacol, Niigata 95021, Japan Niigata CollPharm Niigata Japan 95021 n Pharmacol, Niigata 95021, Japan
Titolo Testata:
JOURNAL OF CARDIAC FAILURE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 138 - 145
SICI:
1071-9164(200106)7:2<138:MAIPWC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR PULSUS ALTERNANS; T-WAVE ALTERNANS; ELECTRICAL ALTERNANS; INTRACELLULAR CALCIUM; CONTRACTILITY; VULNERABILITY; ARRHYTHMIAS; MYOCARDIUM; MUSCLES; DOGS;
Keywords:
mechanical alternans; chronic heart failure; dilated cardiomyopathy; dP/dt; sarcoplasmic reticulum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kodama, M Niigata Univ, Sch Med, Dept Internal Med 1, Asahimachi 1-757, Niigata 9518510, Japan Niigata Univ Asahimachi 1-757 Niigata Japan 9518510 8510, Japan
Citazione:
M. Kodama et al., "Mechanical alternans in patients with chronic heart failure", J CARD FAIL, 7(2), 2001, pp. 138-145

Abstract

Background: Clinical implications of mechanical alternans in patients withchronic heart failure have remained uncertain. In this study, prevalence, characteristics, and prognostic implications of mechanical alternans were investigated. Methods and Results: Consecutive 51 patients with dilated cardiomyopathy underwent diagnostic cardiac catheterization using a micromanometer-tipped catheter. Under basal conditions, 7 of 35 patients with sinus rhythm showed mechanical alternans. Physiologic tachycardia (110 bpm) induced mechanical alternans in another 15 patients with sinus rhythm and in another 10 of 16 patients with atrial fibrillation. Low doses of dobutamine also induced mechanical alternans in another 8 patients, but a high dose of dobutamine eliminated mechanical alternans. Consequently, 40 patients (78%) showed mechanical alternans. Mechanical alternans was always accompanied by alternating changes of positive dP/dt, a parameter of contractility during isovolumetriccontraction time, but negative dP/dt was occasionally constant. Concordantmechanical alternans between both ventricles was more prevalent than discordant alternans. The left ventricular end-diastolic volume indices and end-systolic volume indices of patients with mechanical alternans were larger than those of patients without. The left ventricular ejection fraction of patients with alternans was significantly lower than that of patients without. Conclusions: Mechanical alternans was highly prevalent in patients with chronic heart failure. The origin of mechanical alternans seems to exist before or at the isovolumetric contraction time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:43:01