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Titolo:
beta-adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium
Autore:
Walker, CA; Ergul, A; Grubbs, A; Zile, MR; Zellner, JL; Crumbley, AJ; Spinale, FG;
Indirizzi:
Med Univ S Carolina, Div Cardiothorac Surg Res, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Res, Charleston, SC 29425 USA
Titolo Testata:
JOURNAL OF CARDIAC FAILURE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 129 - 137
SICI:
1071-9164(200106)7:2<129:BAERII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; TACHYCARDIA-INDUCED CARDIOMYOPATHY; ADENYLATE-CYCLASE; CARDIAC MYOCYTES; MECHANISMS; SUBTYPES; DISEASE; EXPRESSION; METOPROLOL; BLOCKADE;
Keywords:
endothelin; beta-adrenergic receptor; congestive heart failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Spinale, FG Rm 625,Strom Thurmond Res Bldg,POB 250778,114 Dou, Charleston,SC 29425 USA Rm 625,Strom Thurmond Res Bldg,POB 250778,114 Dou CharlestonSC USA 29425
Citazione:
C.A. Walker et al., "beta-adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium", J CARD FAIL, 7(2), 2001, pp. 129-137

Abstract

Background: Although end-stage dilated cardiomyopathy (DCM) is characterized by defects in beta -adrenergic receptor (beta -AR) activity and increased endothelin-1 (ET-1), possible interactions between these 2 systems remainto be defined. Accordingly, the goal of this study was to determine the effects of ET receptor activation on beta -AR signaling through measurement of cyclic adenosine monophosphate (cAMP) in normal and DCM myocardium. Methods and Results: Myocardial sarcolemmal preparations were prepared from normal human (n = 6), dilated cardiomyopathic (n = 10), and ischemic cardiomyopathic (ICM, n = 10) tissue. Basal cAMP production was measured in thepresence of ET-1 alone (10(-6) to 0(-9) mol/L) as well as after (-)isoproterenol (10(-6) to 10(-2) mol/L) or forskolin (0.05 to 30.0 mu mol/L) stimulation. beta -AR and ET receptor profiles were determined by radiolabeled ligand assays. ET-1 inhibited basal cAMP production in all preparations in a concentration-dependent manner. However, beta -AR-stimulated cAMP production by either isoproterenol or forskolin was not significantly affected by ET-1. beta -AR receptor density was reduced, and a selective reduction of theETB receptor occurred in both forms of DCM. Conclusions: Under basal conditions, ET receptor stimulation reduced cAMP levels, which may influence contractility, particularly with DCM.

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Documento generato il 10/04/20 alle ore 02:31:55