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Titolo:
Branched nanowire based guanine rich oligonucleotides
Autore:
Zhou, CQ; Tan, ZK; Wang, C; Wei, ZQ; Wang, ZG; Bai, CL; Qin, JF; Cao, EH;
Indirizzi:
Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China Chinese Acad Sci Beijing Peoples R China 100080 100080, Peoples R China Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China Chinese Acad Sci Beijing Peoples R China 100101 100101, Peoples R China
Titolo Testata:
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
fascicolo: 6, volume: 18, anno: 2001,
pagine: 807 - 812
SICI:
0739-1102(200106)18:6<807:BNBGRO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA OLIGOMERS; QUARTET STRUCTURES; G-WIRE; MICROSCOPY; JUNCTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bai, CL Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China Chinese Acad Sci Beijing Peoples R China 100080 Peoples R China
Citazione:
C.Q. Zhou et al., "Branched nanowire based guanine rich oligonucleotides", J BIO STRUC, 18(6), 2001, pp. 807-812

Abstract

Self-assembly and aggregation of guanine rich sequences can provide usefulinsights into DNA nanotechnology and telomeric structure and function. In this paper, we designed a guanine rich sequence d(GGCGTTTTGCGG). We found that it can form stable structure in appropriate condition and it exhibits an anomalous CD spectra. This structures can be imaged in ambient environment with a Nanoscope III AFM (Digital Instruments). We found it forms branch structure and long multistrand DNA nanowire after incubation at 37 degreesCfor 6-12 hours in 25 mM TE (pH=8.0) + 5 mM Mg2+ + 50 mM K+. The ability toself-assemble into branches and long wires not only clearly demonstrate its potential as scaffold structures for nanotechnology, but also give aids to understand telomeric structure further. We have proposed a model to explain how these structures formed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:11:02