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Titolo:
Vascular graft endothelialization: Comparative analysis of canine and human endothelial cell migration on natural biomaterials
Autore:
Dixit, P; Hern-Anderson, D; Ranieri, J; Schmidt, CE;
Indirizzi:
Univ Texas, Dept Chem Engn, Austin, TX 78712 USA Univ Texas Austin TX USA78712 exas, Dept Chem Engn, Austin, TX 78712 USA Sulzer Biol, Austin, TX 78752 USA Sulzer Biol Austin TX USA 78752Sulzer Biol, Austin, TX 78752 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 4, volume: 56, anno: 2001,
pagine: 545 - 555
SICI:
0021-9304(20010915)56:4<545:VGECAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; DYE-MEDIATED PHOTOOXIDATION; POLYTETRAFLUOROETHYLENE GRAFTS; ARTERIAL PROSTHESES; PERICARDIAL TISSUE; DACRON GRAFTS; HEPARIN; PROLIFERATION; MOTILITY; INVIVO;
Keywords:
endothelial cell migration; natural biomaterials; growth factors; adhesion proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, CE Univ Texas, Dept Chem Engn, 26th & Speedway,MC C0400, Austin, TX 78712 USA Univ Texas 26th & Speedway,MC C0400 Austin TX USA 78712 12 USA
Citazione:
P. Dixit et al., "Vascular graft endothelialization: Comparative analysis of canine and human endothelial cell migration on natural biomaterials", J BIOMED MR, 56(4), 2001, pp. 545-555

Abstract

Canines are typically used as the standard preclinical model to gauge the success of vascular graft materials. However, canines spontaneously re-endothelialize vascular grafts, whereas humans do not, even after years. This raises questions of why there are differences in vascular healing between humans and other species and whether the canine is the appropriate preclinical model. In the present study we evaluated human and canine endothelial cell (EC) migration on the novel cross-linked collagen biomaterial PhotoFix (TM) pericardium. We compared in vitro migration of these cells on PhotoFix alone and on PhotoFix adsorbed with various growth factors (aFGF and bFGF) and adhesion proteins (fibronectin, collagen IV, vitronectin, and laminin). We also compared human and canine ECs in terms of their morphologies and prostacyclin production. We found that human umbilical vein ECs (HUVECs) and canine ECs (CECs) migrated well on PhotoFix, suggesting that this biomaterial may be a good vascular graft candidate. Both cell types responded similarly to different growth factors and adhesive proteins, but HUVEC migration was consistently higher than that for CECs. This suggested that human in vivo graft re-endothelialization is likely not hindered by poor endothelial migration but is hindered by other cellular or graft properties. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:35:14