Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain
Autore:
Benson, MA; Newey, SE; Martin-Rendon, E; Hawkes, R; Blake, DJ;
Indirizzi:
Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England Univ OxfordOxford England OX1 3QX Anat & Genet, Oxford OX1 3QX, England Univ Oxford, Dept Biochem, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU Dept Biochem, Oxford OX1 3QU, England Univ Calgary, Fac Med, Dept Cell Biol & Anat & Genes, Calgary, AB T2N 4N1,Canada Univ Calgary Calgary AB Canada T2N 4N1 Genes, Calgary, AB T2N 4N1,Canada Univ Calgary, Fac Med, Dev Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 26, volume: 276, anno: 2001,
pagine: 24232 - 24241
SICI:
0021-9258(20010629)276:26<24232:DANCPT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSTROPHIN-ASSOCIATED PROTEINS; DUCHENNE MUSCULAR-DYSTROPHY; NITRIC-OXIDE SYNTHASE; ALPHA-DYSTROBREVIN; SKELETAL-MUSCLE; BETA-DYSTROBREVIN; COMPLEX; SYNTROPHIN; MOUSE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Benson et al., "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain", J BIOL CHEM, 276(26), 2001, pp. 24232-24241

Abstract

The dystrophin-associated protein complex (DPC) is required for the maintenance of muscle integrity during the mechanical stresses of contraction andrelaxation. In addition to providing a membrane scaffold, members of the DPC such as the alpha -dystrobrevin protein family are thought to play an important role in intracellular signal transduction. To gain additional insights into the function of the DPC, we performed a yeast two-hybrid screen for dystrobrevin-interacting proteins. Here we describe the identification ofa dysbindin, a novel dystrobrevin-binding protein. Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta -dystrobrevin in muscle and brain. Dystrophin and alpha -dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha -dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In thebrain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably messy fiber synaptic terminals in the cerebellum and hippocampus. These findings have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:27:15