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Titolo:
IVF-patients with nonmale factor "to ICSI" or "not to ICSI" that is the question?
Autore:
Poehl, M; Holagschwandtner, M; Bichler, K; Krischker, U; Jurgen, S; Feichtinger, W;
Indirizzi:
Univ Vienna, Dept Obstet & Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 stet & Gynecol, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
fascicolo: 4, volume: 18, anno: 2001,
pagine: 205 - 208
SICI:
1058-0468(200104)18:4<205:IWNF"I>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; MALE FACTOR INFERTILITY; UNEXPLAINED INFERTILITY; INVITRO FERTILIZATION; IMPLANTATION RATES; SIBLING OOCYTES; TUBAL FACTOR; COUPLES; PARAMETERS;
Keywords:
ICSI; IVF; nonmalefactor; tubal infertility capsule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Poehl, M Univ Vienna, Dept Obstet & Gynecol, Wahringerstr 18-20, A-1090 Vienna, Austria Univ Vienna Wahringerstr 18-20 Vienna Austria A-1090 na, Austria
Citazione:
M. Poehl et al., "IVF-patients with nonmale factor "to ICSI" or "not to ICSI" that is the question?", J AS REPROD, 18(4), 2001, pp. 205-208

Abstract

Purpose: Intracytoplasmic sperm injection (ICSI) guarantees high fertilization rates and could theoretically lead to higher implantation rates as well. Furthermore injection into oocyte creates a hole in the zona pellucida similar to the procedure of assisted hatching. We were therefore interested to assess such a potential benefit for infertile IVF patients without male factorMaterials and Methods: Open randomized prospective study according to the rules "Good Clinical Practice" with informed consent of the patients and institutional review board approval. Ninety-one consecutively seen patients with tubal infertility or hostile cervical mucus were randomized to undergo either ICSI (44 patients) or IVF (45 patients). In two patients fertilization of oocytes failed and so a repeated ICSI had to be performed. All these patients were stimulated with tile same protocol, using the gonadotropin releasing hormome-agonist (GnRH-a) buserelin acetate in an ultrashort flair-up protocol together with pure follicle stimulating hormone (rFSH). Tile twostudy groups did nor differ in terms of age BMI, and all baseline hormone levels. Results: Tire total pregnancy rate was 42% in the normal IVF group with 33% ongoing pregnancies The ICSI group had a total pregnancy rate of 39% with23% ongoing pregnancies. The implantation rate per transferred embryo was higher for normal IVF but not significant (18% versus 11%). The variables fertilization rate age body mass index, base-line hormone levels, endometrial thickness, embryo score, and the highest grade embryo per transfer were very similar in both groups. Conclusion: ICSI should be applied only when conventional IVF fails, that is, for male factor patients and for patients with unexplained infertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 10:44:26