Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Signal transduction in smooth muscle - Selected contribution: Airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations
Autore:
Jensen, A; Atileh, H; Suki, B; Ingenito, EP; Lutchen, KR;
Indirizzi:
Boston Univ, Dept Biomed Engn, Resp & Physiol Syst Identificat Lab, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 yst Identificat Lab, Boston, MA 02215 USA Brigham & Womens Hosp, Div Pulm, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Div Pulm, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 506 - 515
SICI:
8750-7587(200107)91:1<506:STISM->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS HISTAMINE; PULMONARY RESPONSE; TISSUE MECHANICS; LUNG-VOLUME; METHACHOLINE; DOGS; BRONCHOCONSTRICTION; PARAMETERS;
Keywords:
airway smooth muscle; airway resistance; methacholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lutchen, KR Boston Univ, Dept Biomed Engn, Resp & Physiol Syst IdentificatLab, 44 Cummington St, Boston, MA 02215 USA Boston Univ 44 Cummington St Boston MA USA 02215 MA 02215 USA
Citazione:
A. Jensen et al., "Signal transduction in smooth muscle - Selected contribution: Airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations", J APP PHYSL, 91(1), 2001, pp. 506-515

Abstract

In 9 healthy and 14 asthmatic subjects before and after a standard bronchial challenge and a modified [deep inspiration (DI), inhibited] bronchial challenge and after albuterol, we tracked airway caliber by synthesizing a method to measure airway resistance (Raw; i.e., lung resistance at 8 Hz) in real time. We determined the minimum Raw achievable during a DI to total lung capacity and the subsequent dynamics of Raw after exhalation and resumption of tidal breathing. Results showed that even after a bronchial challengehealthy subjects can dilate airways maximally, and the dilation caused by a single DI takes several breaths to return to baseline. In contrast, at baseline, asthmatic subjects cannot maximally dilate their airways, and this worsens considerably postconstriction. Moreover, after a DI, the dilation that does occur in airway caliber in asthmatic subjects constricts back to baseline much faster (often after a single breath). After albuterol, asthmatic subjects could dilate airways much closer to levels of those of healthy subjects. These data suggest that the asthmatic smooth muscle resides in a stiffer biological state compared with the stimulated healthy smooth muscle, and inhibiting a DI in healthy subjects cannot mimic this.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 08:20:52