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Titolo:
Signal transduction in smooth muscle - Invited review: Regulation of myosin phosphorylation in smooth muscle
Autore:
Pfitzer, G;
Indirizzi:
Univ Cologne, Dept Physiol, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 t Physiol, D-50931 Cologne, Germany
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 497 - 503
SICI:
8750-7587(200107)91:1<497:STISM->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-CHAIN KINASE; DEPENDENT PROTEIN-KINASE; RHO-ASSOCIATED KINASE; MEDIATED CA2+ SENSITIZATION; PIG TAENIA-COLI; CHICKEN GIZZARD; ARACHIDONIC-ACID; FLASH-PHOTOLYSIS; CALCIUM SENSITIZATION; P21-ACTIVATED KINASE;
Keywords:
calcium sensitivity of smooth muscle contraction; myosin light-chain kinase; myosin light-chain phosphatase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Pfitzer, G Univ Cologne, Dept Physiol, Robert Koch Str 39, D-50931 Cologne, Germany Univ Cologne Robert Koch Str 39 Cologne Germany D-50931 ermany
Citazione:
G. Pfitzer, "Signal transduction in smooth muscle - Invited review: Regulation of myosin phosphorylation in smooth muscle", J APP PHYSL, 91(1), 2001, pp. 497-503

Abstract

Phosphorylation of the regulatory light chains of myosin II (rMLC) by the Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) and dephosphorylation by a type 1 phosphatase (MLCP), which is targeted to myosin by a regulatory subunit (MYPT1), are the predominant mechanisms of regulation of smooth muscle tone. The activities of both enzymes are modulated by several protein kinases. MLCK is inhibited by the Ca2+/calmodulin-dependent protein kinase II, whereas the activity of MLCP is increased by cGMP and perhaps also cAMP-dependent protein kinases. In either case, this results in a decrease in the Ca2+ sensitivity of rMLC phosphorylation and force production. Theactivity of MLCP is inhibited by Rho-associated kinase, one of the effectors of the monomeric GTPase Rho, and protein kinase C, leading to an increase in Ca2+ sensitivity. Hence, smooth muscle tone appears to be regulated bya network of activating and inactivating intracellular signaling cascades.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:53:04