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Titolo:
A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs
Autore:
Tsoukias, NM; Shin, HW; Wilson, AF; George, SC;
Indirizzi:
Univ Calif Irvine, Dept Chem & Biochem Engn & Mat Sci, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ngn & Mat Sci, Irvine, CA 92697 USA Univ Calif Irvine, Dept Med, Ctr Biomed Engn, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 r Biomed Engn, Irvine, CA 92697 USA Univ Calif Irvine, Div Pulm & Crit Care, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 m & Crit Care, Irvine, CA 92697 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 477 - 487
SICI:
8750-7587(200107)91:1<477:ASTWVF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXHALED AIR; HUMANS; AIRWAYS; RECOMMENDATIONS; EPITHELIUM; ASTHMA;
Keywords:
parameter estimation; diffusing capacity; airways; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: George, SC Univ Calif Irvine, Dept Chem & Biochem Engn & Mat Sci, 916 EngnTower, Irvine, CA 92697 USA Univ Calif Irvine 916 Engn Tower Irvine CA USA92697 92697 USA
Citazione:
N.M. Tsoukias et al., "A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs", J APP PHYSL, 91(1), 2001, pp. 477-487

Abstract

Current techniques to estimate nitric oxide (NO) production and elimination in the lungs are inherently nonspecific or are cumbersome to perform (multiple-breathing maneuvers). We present a new technique capable of estimating key flow-independent parameters characteristic of NO exchange in the lungs: 1) the steady-state alveolar concentration (C-alv,C-ss), 2) the maximum flux of NO from the airways (J(NO, max)), and 3) the diffusing capacity of NO in the airways (D-NO,D-air). Importantly, the parameters were estimated from a single experimental single-exhalation maneuver that consisted of a preexpiratory breath hold, followed by an exhalation in which the flow rate progressively decreased. The mean values for J(NO,max), D-NO,D-air, and C-alv,C-ss do not depend on breath-hold time and range from 280-600 pl/s, 3.7-7.1 pl.s(-1).parts per billion (ppb)(-1), and 0.73-2.2 ppb, respectively, in two healthy human subjects. A priori estimates of the parameter confidence intervals demonstrate that a breath hold no longer than 20 s may be adequate and that J(NO,max) can be estimated with the smallest uncertainty and D-NO,D-air with the largest, which is consistent with theoretical predictions. We conclude that our new technique can be used to characterize flow-independent NO exchange parameters from a single experimental single-exhalationbreathing maneuver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:03:40