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Titolo:
alpha-Actin: disposition, quantities, and estimated effects on lung recoiland compliance
Autore:
Oldmixon, EH; Carlsson, K; Kuhn, C; Butler, JP; Hoppin, FG;
Indirizzi:
Mem Hosp Rhode Isl, Dept Med, Div Pulm & Crit Care Med, Pawtucket, RI 02860 USA Mem Hosp Rhode Isl Pawtucket RI USA 02860 re Med, Pawtucket, RI 02860 USA Mem Hosp Rhode Isl, Dept Pathol, Pawtucket, RI 02860 USA Mem Hosp Rhode Isl Pawtucket RI USA 02860 Pathol, Pawtucket, RI 02860 USA Brown Univ, Pawtucket, RI 02860 USA Brown Univ Pawtucket RI USA 02860Brown Univ, Pawtucket, RI 02860 USA Royal Inst Technol, SE-10044 Stockholm, Sweden Royal Inst Technol Stockholm Sweden SE-10044 SE-10044 Stockholm, Sweden Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02114 USA HarvardUniv Boston MA USA 02114 h, Physiol Program, Boston, MA 02114 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 459 - 473
SICI:
8750-7587(200107)91:1<459:ADQAEE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY SMOOTH-MUSCLE; VENTILATION DISTRIBUTION; INTERSTITIAL-CELLS; ALVEOLAR SEPTA; DOG LUNGS; RAT LUNG; TISSUE; MECHANICS; CONSTRICTION; VOLUME;
Keywords:
alveolar duct; intensity-modulated multiple-wavelength; scanning confocal microscopy; lung compliance; ventilation-perfusion ratio; hypocapnia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hoppin, FG Mem Hosp Rhode Isl, Dept Med, Div Pulm & Crit Care Med, 111 Brewster St, Pawtucket, RI 02860 USA Mem Hosp Rhode Isl 111 Brewster St Pawtucket RI USA 02860 0 USA
Citazione:
E.H. Oldmixon et al., "alpha-Actin: disposition, quantities, and estimated effects on lung recoiland compliance", J APP PHYSL, 91(1), 2001, pp. 459-473

Abstract

We have investigated the basis and implications of pneumoconstriction by measuring disposition and quantities of alpha -smooth muscle actin in rat and guinea pig lungs and modeling its effects on lung recoil and compliance. A robust marker of contractility, alpha -smooth muscle actin appears in smooth muscle or myofibroblast-like cells in pleura, airways, blood vessels, and alveolar ductal tissues. In each site, we measured its transected area by immunofluorescent staining and frequency-modulated scanning confocal microscopy. We incorporated these data in a model of the parenchyma consisting of an extensive elastic network with embedded contractile structures. We conclude that contraction at any one of these sites alone can decrease parenchymal compliance by 20-30% during tidal breathing. This is due mostly to the stiffness of activated contractile elements undergoing passive cycling; constant muscle tension would have little effect. The magnitude of the effect corresponds with known responses of the lung to hypocapnia, consistent with a homeostatic function in which gas exchange is defended by redistributing ventilation away from overventilated units.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:48:51