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Titolo:
Impaired distensibility of the left ventricle after stiffening of the right ventricle
Autore:
Shirakabe, M; Yamaguchi, S; Tamada, Y; Baniya, G; Fukui, A; Miyawaki, H; Tomoike, H;
Indirizzi:
Yamagata Univ, Sch Med, Dept Internal Med 1, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 rnal Med 1, Yamagata 9909585, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 435 - 440
SICI:
8750-7587(200107)91:1<435:IDOTLV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESSURE-VOLUME RELATIONSHIP; SEPTAL DISPLACEMENT; DIASTOLIC STIFFNESS; SYSTOLIC FUNCTION; REGIONAL PRELOAD; CONSCIOUS DOG; FREE-WALL; INTERDEPENDENCE; MODEL; HYPERTENSION;
Keywords:
ventricular interdependence; ventricular geometry; left ventricular stiffness; diastolic function; length-tension relation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, S Yamagata Univ, Sch Med, Dept Internal Med 1, 2-2-2 Iida Nishi, Yamagata 9909585, Japan Yamagata Univ 2-2-2 Iida Nishi Yamagata Japan 9909585 Japan
Citazione:
M. Shirakabe et al., "Impaired distensibility of the left ventricle after stiffening of the right ventricle", J APP PHYSL, 91(1), 2001, pp. 435-440

Abstract

Acute and chronic alterations of right ventricular (RV) wall properties can change left ventricular (LV) performance. We investigated whether and howstiffening of the RV free wall alters LV diastolic distensibility. We usedcross-circulated isolated hearts, in which the LV and RV were independently controllable. Stiffness of the RV free wall was altered by intramuscular injections of glutaraldehyde into the RV free wall after right coronary artery ligation. We measured circumferential and longitudinal regional lengthsin the septum and LV free wall. During data acquisition, RV volume was held constant. After the RV free wall was stiffened by glutaraldehyde, the LV diastolic pressure-volume relation shifted upward and became steeper. Importantly, stiffening of the RV free wall increased the diastolic regional area in the septum and LV free wall under constant LV volume. The augmented regional dimensions may result in enhanced regional tension under constant LVvolume and may be related to the observed increase in LV diastolic intracavitary pressure. The impaired LV diastolic distensibility by stiffening of the RV free wall may be at least partly explained by myocardial stretch, probably due to LV deformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:20:52