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Titolo:
Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla
Autore:
Mazza, E; Thakkar-Varia, S; Tozzi, CA; Neubauer, JA;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Div Pulm & Crit Care Med, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08903 swick, NJ 08903 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08903 swick, NJ 08903 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 379 - 385
SICI:
8750-7587(200107)91:1<379:EOHOIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL RESPIRATORY-CHAIN; LONG-TERM POTENTIATION; CAT CAROTID-BODY; CARBON-MONOXIDE; RAT-BRAIN; NITRIC-OXIDE; IN-VIVO; GUANYLATE-CYCLASE; MESSENGER-RNA; HYPOXIA;
Keywords:
oxygen chemosensitivity; respiration; sympathetic; chronic hypoxia; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Neubauer, JA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, DeptMed, Div Pulm & Crit Care Med, 1 Robert Wood Johnson Pl,POB 19, New Brunswick, NJ 08903USA Univ Med & Dent New Jersey 1 Robert Wood Johnson Pl,POB 19New Brunswick NJ USA 08903
Citazione:
E. Mazza et al., "Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla", J APP PHYSL, 91(1), 2001, pp. 379-385

Abstract

Recently, unique regions in the rostral ventrolateral medulla (RVLM) have been found to be oxygen sensitive. However, the mechanism of sensing oxygenin these RVLM regions is unknown. Because heme oxygenase (HO) has been shown to be involved in the hypoxic responses of the carotid body and pulmonary artery, the aim of this study was to determine whether HO is present in the RVLM and whether expression of HO is altered by chronic hypoxia. Adult rats were exposed to hypoxia (10% O-2) or normoxia (21% O-2) for 10 days, and the mRNA for HO-1 and HO-2 was examined in the RVLM by using RT-PCR. Expression of HO-2 mRNA was seen in the RVLM of both control and hypoxic samples, whereas expression of HO-1 mRNA was only seen in the RVLM of hypoxic samples. HO-2 was immunocytochemically localized in brain sections (40 mum) tothe C1 region and pre-Botzinger complex of the RVLM. Together, these results indicate that HO-2 is present in the RVLM under control conditions and that HO-1 is induced in the RVLM during chronic hypoxia, consistent with a potential role for HO in the oxygen-sensing function of these cardiorespiratory RVLM regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:38:25