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Titolo:
Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia
Autore:
Rodman, JR; Curran, AK; Henderson, KS; Dempsey, JA; Smith, CA;
Indirizzi:
Univ Wisconsin, Sch Med, John Rankin Lab Pulm Med, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 n Lab Pulm Med, Madison, WI 53705 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 328 - 335
SICI:
8750-7587(200107)91:1<328:CBDIDE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-DIOXIDE; HYPOXIA; CO2; CHEMORECEPTOR; HYPOVENTILATION; EXCISION; PRESSURE; OXYGEN; BODIES; CATS;
Keywords:
chemoreception; ventilatory control; compensation; rebreathing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Rodman, JR 504 N Walnut St, Madison, WI 53705 USA 504 N Walnut St MadisonWI USA 53705 St, Madison, WI 53705 USA
Citazione:
J.R. Rodman et al., "Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia", J APP PHYSL, 91(1), 2001, pp. 328-335

Abstract

We assessed the time course of changes in eupneic arterial PCO2 (Pa-CO2) and the ventilatory response to hyperoxic rebreathing after removal of the carotid bodies (CBX) in awake female dogs. Elimination of the ventilatory response to bolus intravenous injections of NaCN was used to confirm CBX status on each day of data collection. Relative to eupneic control (Pa-CO2 = 40+/- 3 Torr), all seven dogs hypoventilated after CBX, reaching a maximum Pa-CO2 of 53 +/- 6 Torr by day 3 post-CBX. There was no significant recoveryof eupneic PaCO2 over the ensuing 18 days. Relative to control, the hyperoxic CO2 ventilatory (change in inspired minute ventilation/change in end-tidal PCO2) and tidal volume (change in tidal volume/change in end-tidal PCO2) response slopes were decreased 40 +/- 15 and 35 +/- 20% by day 2 post-CBX. There was no recovery in the ventilatory or tidal volume response slopes to hyperoxic hypercapnia over the ensuing 19 days. We conclude that 1) the carotid bodies contribute similar to 40% of the eupneic drive to breathe and the ventilatory response to hyperoxic hypercapnia and 2) there is no recovery in the eupneic drive to breathe or the ventilatory response to hyperoxic hypercapnia after removal of the carotid chemoreceptors, indicating a lack of central or aortic chemoreceptor plasticity in the adult dog after CBX.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:53:22