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Titolo:
Pronounced effect of minor changes in body temperature on ischemia and reperfusion injury in rat liver
Autore:
Heijnen, BHM; van Veen, SQ; Straatsburg, IH; van Gulik, TM;
Indirizzi:
Acad Med Ctr, Surg Lab, NL-1105 AZ Amsterdam, Netherlands Acad Med Ctr Amsterdam Netherlands NL-1105 AZ AZ Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 265 - 268
SICI:
8750-7587(200107)91:1<265:PEOMCI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; FASTED RATS; ISOFLURANE; HALOTHANE; TISSUES; MODEL;
Keywords:
hypothermia; hyperthermia; alpha-glutathione S-transferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Heijnen, BHM Acad Med Ctr, Surg Lab, IWO 1-151,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Acad Med Ctr IWO 1-151,Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
B.H.M. Heijnen et al., "Pronounced effect of minor changes in body temperature on ischemia and reperfusion injury in rat liver", J APP PHYSL, 91(1), 2001, pp. 265-268

Abstract

This study examined the effects of 1 degreesC hypo- or hyperthermia on in vivo liver ischemia and reperfusion (I/R) injury in 15 fasted male Wistar rats. Rats were ventilated, and rectal temperature was maintained at 36, 37 (normothermic), or 38 degreesC. In all rats, 70% liver ischemia was inducedby clamping the afferent vessels to the median and left lateral lobes for 60 min, and reperfusion was allowed for 90 min. Changes in plasma aspartateaminotransferase (AST), alanine aminotransferase (ALT), and alpha -glutathione S-transferase (alpha -GST) levels were measured, hemodynamics and bilesecretion were monitored, and arterial blood-gas analysis was performed. All ventilated rats showed a normal pH, arterial PCO2, and arterial PO2. AST, ALT, and alpha -GST levels were significantly higher in the 38 degreesC group when compared with the 36 and 37 degreesC groups after ischemia. No differences in bile secretion were found between all groups. Histopathological alterations were in agreement with AST, ALT, and alpha -GST levels in plasma. We conclude that a decrease of only 1 degreesC in body temperature significantly attenuates liver I/R injury, whereas an increase of 1 degreesC significantly increases liver I/R injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:41:46