Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats
Autore:
Saengsirisuwan, V; Kinnick, TR; Schmit, MB; Henriksen, EJ;
Indirizzi:
Univ Arizona, Coll Med, Dept Physiol, Muscle Metab Lab, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 , Muscle Metab Lab, Tucson, AZ 85721 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 145 - 153
SICI:
8750-7587(200107)91:1<145:IOETAL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE; THIOCTIC ACID; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; STIMULATION; PATHWAY; GLUT-4; TRANSLOCATION; ANTIOXIDANT; ACTIVATION;
Keywords:
insulin resistance; oxidative stress; glucose tolerance; GLUT-4 protein; protein carbonyls;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Henriksen, EJ Univ Arizona, Coll Med, Dept Physiol, Muscle Metab Lab, Ina E Gittings Bldg 93, Tucson, AZ 85721 USA Univ Arizona Ina E Gittings Bldg 93 Tucson AZ USA 85721 USA
Citazione:
V. Saengsirisuwan et al., "Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats", J APP PHYSL, 91(1), 2001, pp. 145-153

Abstract

Exercise training (ET) or the antioxidant R(+)-alpha -lipoic acid (R-ALA) individually increases insulin action in the insulin-resistant obese Zuckerrat. The purpose of the present study was to determine the interactions ofET and R-ALA on insulin action and oxidative stress in skeletal muscle of the obese Zucker rat. Animals either remained sedentary, received R-ALA (30mg.kg body wt(-1).day(-1)), performed ET (treadmill running), or underwentboth R-ALA treatment and ET for 6 wk. During an oral glucose tolerance test, ET alone or in combination with R-ALA resulted in a significant loweringof the glucose (26-32%) and insulin (29-30%) responses compared with sedentary controls. R-ALA alone decreased (19%) the glucose-insulin index (indicative of increased insulin sensitivity), and this parameter was reduced (48-52%) to the greatest extent in the ET and combined treatment groups. ET orR-ALA individually increased insulin-mediated glucose transport activity in isolated epitrochlearis (44-48%) and soleus (37-57%) muscles. The greatest increases in insulin action in these muscles (80 and 99%, respectively) were observed in the combined treatment group. Whereas the improvement in insulin-mediated glucose transport in soleus due to R-ALA was associated withdecreased protein carbonyl levels (an index of oxidative stress), improvement because of ET was associated with decreased protein carbonyls as well as enhanced GLUT-4 protein. However, there was no interactive effect of ET and R-ALA on GLUT-4 protein or protein carbonyl levels. These results indicate that ET and R-ALA interact in an additive fashion to improve insulin action in insulin-resistant skeletal muscle. Because the further improvement in muscle glucose transport in the combined group was not associated with additional upregulation of GLUT-4 protein or a further reduction in oxidativestress, the mechanism for this interaction must be due to additional, as yet unidentified, factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:28:29