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Titolo:
Blood-brain barrier permeability during dopamine-induced hypertension in fetal sheep
Autore:
Harris, AP; Robinson, R; Koehler, RC; Traystman, RJ; Gleason, CA;
Indirizzi:
Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 re Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Pediat, Baltimore, MD 21287 USA Univ Washington, Dept Pediat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pediat, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 123 - 129
SICI:
8750-7587(200107)91:1<123:BBPDDH>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-AMINOISOBUTYRIC-ACID; SUPEROXIDE-DISMUTASE; PRETERM INFANT; OVINE FETUS; FLOW; TRANSPORT; METABOLISM; DOBUTAMINE; DISRUPTION; CAPILLARY;
Keywords:
aminoisobutyric acid; blood pressure; cerebral edema; fetus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Koehler, RC Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, 600 N Wolfe St,Blalock 1404, Baltimore, MD 21287 USA Johns Hopkins Med Inst 600N Wolfe St,Blalock 1404 Baltimore MD USA 21287
Citazione:
A.P. Harris et al., "Blood-brain barrier permeability during dopamine-induced hypertension in fetal sheep", J APP PHYSL, 91(1), 2001, pp. 123-129

Abstract

Dopamine is often used as a pressor agent in sick newborn infants, but an increase in arterial blood pressure could disrupt the blood-brain barrier (BBB), especially in the preterm newborn. Using time-dated pregnant sheep, we tested the hypothesis that dopamine-induced hypertension increases fetal BBB permeability and cerebral water content. Barrier permeability was assessed in nine brain regions, including cerebral cortex, caudate, thalamus, brain stem, cerebellum, and spinal cord, by intravenous injection of the small tracer molecule [C-14] aminoisobutyric acid at 10 min after the start of dopamine or saline infusion. We studied 23 chronically catheterized fetal sheep at 0.6 (93 days, n = 10) and 0.9 (132 days, n = 13) gestation. Intravenous infusion of dopamine increased mean arterial pressure from 38 +/- 3 to53 +/- 5 mmHg in 93-day fetuses and from 55 +/- 5 to 77 +/- 8 mmHg in 132-day fetuses without a decrease in arterial O-2 content. These 40% increasesin arterial pressure are close to the maximum hypertension reported for physiological stresses at these ages in fetal sheep. No significant increasesin the brain transfer coefficient of aminoisobutyric acid were detected inany brain region in dopamine-treated fetuses compared with saline controlsat 0.6 or 0.9 gestation. There was also no significant increase in cortical water content with dopamine infusion at either age. We conclude that a 40% increase in mean arterial pressure during dopamine infusion in normoxic fetal sheep does not produce substantial BBB disruption or cerebral edema even as early as 0.6 gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:35:14