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Titolo:
Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity
Autore:
Kostyak, JC; Kimball, SR; Jefferson, LS; Farrell, PA;
Indirizzi:
Penn State Univ, Noll Physiol Res Ctr 119, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 9, University Pk, PA 16802 USA Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 l, University Pk, PA 16802 USA Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 & Mol Physiol, Hershey, PA 17033 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 79 - 84
SICI:
8750-7587(200107)91:1<79:SDIREI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-EXCHANGE FACTOR; GLYCOGEN-SYNTHASE KINASE-3; MUSCLE PROTEIN-SYNTHESIS; SKELETAL-MUSCLE; TRANSLATION INITIATION; GLYCEMIC CONTROL; INSULIN; RATS; PHOSPHORYLATION; PROTEOLYSIS;
Keywords:
insulin; mRNA translation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Farrell, PA Penn State Univ, Noll Physiol Res Ctr 119, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 y Pk, PA 16802 USA
Citazione:
J.C. Kostyak et al., "Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity", J APP PHYSL, 91(1), 2001, pp. 79-84

Abstract

Rates of protein synthesis are reduced in severely diabetic rats. A potential mechanism through which insulin can stimulate protein synthesis is modulation of the activity of eukaryotic initiation factor 2B (eIF2B). The activity of this factor is elevated after exercise in nondiabetic rats but is markedly lower in skeletal muscle from nonexercised severely diabetic rats. We tested the hypothesis that a failure to increase eIF2B activity after exercise is one potential reason for a failure of severely diabetic rats to increase rates of protein synthesis after resistance exercise. Diabetic (partial pancreatectomy, plasma glucose >475 mg/dl) and nondiabetic male Sprague-Dawley rats (similar to 300 g) performed acute moderate-intensity resistance exercise or remained sedentary. Rates of protein synthesis were higher in nondiabetic rats and increased significantly with exercise, while no elevation was found in severely diabetic rats. The activity of eIF2B was higher (P < 0.05) in exercised nondiabetic than in sedentary nondiabetic rats (0.096 <plus/minus> 0.016 and 0.064 +/- 0.02 pmol GDP exchanged/min, respectively), but no difference was observed between sedentary and exercised diabetic rats (0.037 +/- 0.001 and 0.044 +/- 0.008 pmol GDP exchanged/min, respectively), and these activities were lower (P, 0.05) than in nondiabetic animals. These data suggest that severe hypoinsulinemia is associated with an inability to increase eIF2B activity in response to exercise.

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Documento generato il 29/03/20 alle ore 15:08:10