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Titolo:
Physiological consequences of oxygen-dependent chloride binding to hemoglobin
Autore:
Prange, HD; Shoemaker, JL; Westen, EA; Horstkotte, DG; Pinshow, B;
Indirizzi:
Indiana Univ, Med Sci Program, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 Program, Bloomington, IN 47405 USA Ben Gurion Univ Negev, Jacob Blaustein Inst Desert Res, IL-84990 Sede Boqer, Israel Ben Gurion Univ Negev Sede Boqer Israel IL-84990 4990 Sede Boqer, Israel Ben Gurion Univ Negev, Dept Life Sci, IL-84990 Sede Boqer, Israel Ben Gurion Univ Negev Sede Boqer Israel IL-84990 4990 Sede Boqer, Israel
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 91, anno: 2001,
pagine: 33 - 38
SICI:
8750-7587(200107)91:1<33:PCOOCB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-BLOOD-CELLS; CHEMICAL MODIFICATION; HUMAN DEOXYHEMOGLOBIN; EQUILIBRIA; TRANSPORT; AFFINITY; SITES; OXYHEMOGLOBIN; BICARBONATE; PHOSPHATE;
Keywords:
blood-gas transport; Donnan ratio; Bohr effect; Haldane effect; strong ion difference; bicarbonate; erythrocyte; chloride shift;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Prange, HD Indiana Univ, Med Sci Program, Jordan Hall 104,1001 E 3rd St, Bloomington,IN 47405 USA Indiana Univ Jordan Hall 104,1001 E 3rd St Bloomington IN USA 47405
Citazione:
H.D. Prange et al., "Physiological consequences of oxygen-dependent chloride binding to hemoglobin", J APP PHYSL, 91(1), 2001, pp. 33-38

Abstract

The PO2-dependent binding of chloride to Hb decreases the Cl- concentration of the red blood cell (RBC) intracellular fluid in venous blood to similar to1-3 mmol/l less than that in arterial blood. This change is physiologically important because 1) Cl- is a negative heterotropic allosteric effector of Hb that competes for binding sites with 2,3-bisphosphoglycerate and CO2 and decreases oxyhemoglobin affinity in several species; 2) it may help reconcile several longstanding problems with measured values of the Donnan ratios for Cl-, HCO3-, and H+ across the RBC membrane that are used to calculate total CO2 carriage, ion flux rates, and membrane potentials; 3) it is a factor in the change in the dissociation constant for the combined nonvolatile weak acids of Hb associated with the Haldane effect; and 4) it diminishes the decrease in strong ion difference in the RBC intracellular fluid that would otherwise occur from the chloride shift and prevent the known increase of HCO3- concentration in that compartment.

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Documento generato il 29/03/20 alle ore 12:15:22