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Titolo:
Structural analysis of a novel antimutagenic compound, 4-hydroxypanduratinA, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult) against mutagenic heterocyclic amines
Autore:
Trakoontivakorn, G; Nakahara, K; Shinmoto, H; Takenaka, M; Onishi-Kameyama, M; Ono, H; Yoshida, M; Nagata, T; Tsushida, T;
Indirizzi:
JIRCAS, Tsukuba, Ibaraki 3058686, Japan JIRCAS Tsukuba Ibaraki Japan 3058686 CAS, Tsukuba, Ibaraki 3058686, Japan Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan Natl Food Res Inst Tsukuba Ibaraki Japan 3058642 , Ibaraki 3058642, Japan Kasetsart Univ, Inst Food Res & Prod Dev, Bangkok 10903, Thailand Kasetsart Univ Bangkok Thailand 10903 Prod Dev, Bangkok 10903, Thailand
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 6, volume: 49, anno: 2001,
pagine: 3046 - 3050
SICI:
0021-8561(200106)49:6<3046:SAOANA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC-ACTIVATION; KAEMPFERIA-PANDURATA; CONSTITUENTS; INHIBITION; CARCINOGEN; MICROSOMES;
Keywords:
antimutagen; fingerroot (Boesenbergia pandurata Schult); Ames test; Trp-P-1; 4-hydroxypanduratin A; Thailand; JIRCAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nakahara, K JIRCAS, 1-2 Owashi, Tsukuba, Ibaraki 3058686, Japan JIRCAS 1-2Owashi Tsukuba Ibaraki Japan 3058686 3058686, Japan
Citazione:
G. Trakoontivakorn et al., "Structural analysis of a novel antimutagenic compound, 4-hydroxypanduratinA, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult) against mutagenic heterocyclic amines", J AGR FOOD, 49(6), 2001, pp. 3046-3050

Abstract

Six compounds were isolated from fresh rhizomes of fingerroot (Boesenbergia pandurata Schult.) as Strong antimutagens toward 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in Salmonella typhimurium TA98. These compounds were 2 ' ,4 ' ,6 ' -trihydroxychalcone (pinocembrin chalcone; 1), 2 ' ,4' -dihydroxy-6 ' -methoxychalcone (cardamonin; 2), 5,7-dihydroxyflavanone (pinocembrin; 3), 5-hydroxy-7-methoxyflavanone (pinostrobin; 4), (2,4,6-trihydroxyphenyl)-[3 ' -methyl-2 '-(3 " -methylbut-2 " -enyl)-6 ' -phenylcyclohex-3 ' -enyl]methanone (5), and (2,6-dihydroxy-4-methoxyphenyl)- [3 ' -methyl-2 '-(3 " -methylbut-2 " -enyl)-6 ' -phenylcyclohex-3 ' -enyl]methanone (panduratin A; 6). Compound 5 was a novel compound (tentatively termed 4-hydroxypanduratin A), and 1 was not previously reported in:this plant, whereas 2-4 and 6 were known compounds. The antimutagenic IC50 values of compounds 1-6 were 5.2 +/- 0.4, 5.9 +/- 0.7, 6.9 +/- 0.8, 5.3 +/- 1.0, 12.7 +/- 0.7, and 12.1 +/- 0.8 muM in the preincubation mixture, respectively. They also similarly inhibited the mutagenicity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). All;of them strongly inhibited the N-hydroxylation of Trp-P-2. Thus, theantimutagenic effect of compounds 1-6 was mainly due to the inhibition of the first step of enzymatic activation of heterocyclic amines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:42:06