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Titolo:
Spiral ligament pathology: A major aspect of age-related cochlear degeneration in C57BL/6 mice
Autore:
Hequembourg, S; Liberman, MC;
Indirizzi:
Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA Massachusetts Eye & Ear Infirm Boston MA USA 02114 , Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 pt Otol & Laryngol, Boston, MA 02114 USA
Titolo Testata:
JARO
fascicolo: 2, volume: 2, anno: 2001,
pagine: 118 - 129
SICI:
1525-3961(200106)2:2<118:SLPAMA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIR CELL LOSS; LATERAL WALL; HEARING-LOSS; INNER-EAR; MOUSE; NERVE; FIBROCYTES; EXPRESSION; STRIA; CATS;
Keywords:
cochlea; hearing; histopathology; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Liberman, MC Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston,MA 02114 USA Massachusetts Eye & Ear Infirm 243 Charles St Boston MA USA 02114
Citazione:
S. Hequembourg e M.C. Liberman, "Spiral ligament pathology: A major aspect of age-related cochlear degeneration in C57BL/6 mice", JARO, 2(2), 2001, pp. 118-129

Abstract

Data from systematic, light microscopic examination of cochlear histopathology in an age-graded series of C57BL/6 mice (1.5-15 months) were compared with threshold elevations (measured by auditory brain stem response) to elucidate the functionally important structural changes underlying age-relatedhearing loss in this inbred strain. In addition to quantifying the degree and extent of hail cell and neuronal loss, all structures of the cochlear duct were qualitatively evaluated and any degenerative changes were quantified. Hair cell and neuronal loss patterns suggested two degenerative processes. In the basal half of the cochlea, inner and outer hair cell loss proceeded fi om base to apex with increasing age, and loss of cochlear neurons Tvas consistent with degeneration occurring secondary to inner hair cell loss. In the apical half of the cochlea with advancing age, there was selectiveloss of outer hair cells which increased from the middle to the extreme apex. A similar gradient of ganglion cell loss was noted, characterized by widespread somatic aggregation and demyelination. In addition to these changes in hair cells and their innervation, there was widespread degeneration offibrocytes in the spiral ligament, especially among the type IV cell class. The cell loss in the ligament preceded the loss of hair cells and/or neurons in both space and time suggesting that fibrocyte pathology may be a primary cause of the hearing loss and ultimate sensory cell degeneration in this mouse strain.

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Documento generato il 22/02/20 alle ore 17:54:09