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Titolo:
Large-scale analysis of mutations in RET exon 16 in sporadic medullary thyroid carcinomas in Japan
Autore:
Takano, T; Miyauchi, A; Yoshida, H; Hasegawa, Y; Kuma, K; Amino, N;
Indirizzi:
Osaka Univ, Sch Med, Dept Lab Med, Suita, Osaka 5650871, Japan Osaka UnivSuita Osaka Japan 5650871 Lab Med, Suita, Osaka 5650871, Japan Kuma Hosp, Chuo Ku, Kobe, Hyogo 6500011, Japan Kuma Hosp Kobe Hyogo Japan6500011 p, Chuo Ku, Kobe, Hyogo 6500011, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 6, volume: 92, anno: 2001,
pagine: 645 - 648
SICI:
0910-5050(200106)92:6<645:LAOMIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOPLASIA TYPE 2B; SOMATIC MUTATIONS; TYROSINE KINASE; POINT MUTATIONS; PROTOONCOGENE; ONCOGENE; CANCER; DOMAIN;
Keywords:
somatic mutation; thyroid medullary carcinoma; RET; Japanese; PCR-RFLP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takano, T Osaka Univ, Sch Med, Dept Lab Med, D2 2-2 Yamadaoka, Suita, Osaka 5650871,Japan Osaka Univ D2 2-2 Yamadaoka Suita Osaka Japan 5650871 0871,Japan
Citazione:
T. Takano et al., "Large-scale analysis of mutations in RET exon 16 in sporadic medullary thyroid carcinomas in Japan", JPN J CANC, 92(6), 2001, pp. 645-648

Abstract

Germline mutations in the RET proto-oncogene are the cause of multiple endocrine neoplasia type 2 (MEN 2A and 2B) and familial medullary thyroid carcinoma (FMTC), Some cases of sporadic medullary thyroid carcinoma (MTC) havealso been reported to have mutations in the RET gene. However, two previous reports have given discrepant results on the frequency of the mutations in RET in sporadic MTCs in Japan. To clarify this problem, we analyzed mutations in RET exon 16 in 72 sporadic MTCs hg means of the two methods used inthe previous studies, direct sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), Mutations in exon 16 were detected in only 2 of 72 cases of sporadic MTC. These results suggest that when a MTC has a mutation in RET exon 16, it is more likely to be a hereditary MTC than a sporadic one in Japan.

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Documento generato il 23/01/20 alle ore 06:21:42