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Titolo:
MODEL OF MILK PROTEIN-SYNTHESIS - A MECHANISTIC MODEL OF MILK PROTEIN-SYNTHESIS IN THE LACTATING BOVINE MAMMARY-GLAND
Autore:
MAAS JA; FRANCE J; MCBRIDE BW;
Indirizzi:
UNIV GUELPH,DEPT ANIM & POULTRY SCI GUELPH ON N1G 2W1 CANADA INST GRASSLAND & ENVIRONM RES OKEHAMPTON EX20 2SB DEVON ENGLAND
Titolo Testata:
Journal of theoretical biology
fascicolo: 3, volume: 187, anno: 1997,
pagine: 363 - 378
SICI:
0022-5193(1997)187:3<363:MOMP-A>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-TRANSPORT; GENE-EXPRESSION; MULTICOMPONENT ANALYSIS; ABOMASAL INFUSIONS; MAMMALIAN-CELLS; ANIMAL-CELLS; GROWTH-RATE; SYSTEM-L; METABOLISM; CASEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Maas et al., "MODEL OF MILK PROTEIN-SYNTHESIS - A MECHANISTIC MODEL OF MILK PROTEIN-SYNTHESIS IN THE LACTATING BOVINE MAMMARY-GLAND", Journal of theoretical biology, 187(3), 1997, pp. 363-378

Abstract

A model of amino acid (AA) uptake and metabolism by the mammary gland(udder) of a high-producing dairy cow in mid-lactation is presented. Two cell types, milk-secreting alveolar epithelial cells, and constitutive stromal cells are represented separately. Solution of the model at steady state, with appropriate assumptions, allows calculation of amino acid (AA) pool sizes in tissue bound AA and mirk protein bound AA,and concentrations of intracellular free AA. Bidirectional flux ratesof amino acids between each of these pools is also estimated. The flow of two amino acids, phenylalanine (Phe) and tyrosine (Tyr), is described using uptake kinetics of the L-system AA transporter. Model results suggest that AA uptake capacity of the alveolar cells, and the amount/activity of protein translation components limit the rate of milk protein synthesis in the high-producing dairy cow. A considerable amount of experimental work is necessary to provide data, if a comprehensive quantitative understanding of milk protein synthesis is to be achieved. (C) 1997 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:43:18