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Titolo:
Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression
Autore:
Chiu, LCM; Ooi, VEC; Sun, SSM;
Indirizzi:
Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 137 - 141
SICI:
1019-6439(200107)19:1<137:IOABAR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; IMMUNOTOXINS; RICIN; DIFFERENTIATION; LEUKEMIA; THERAPY; SITE; BAX;
Keywords:
agrostin; anti-proliferation; apoptosis; bcl-2; flow cytometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chiu, LCM Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China China
Citazione:
L.C.M. Chiu et al., "Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression", INT J ONCOL, 19(1), 2001, pp. 137-141

Abstract

Agrostin is a type 1 ribosome-inactivating protein (RIP) isolated from theseeds of Agrostemma githago. (3)[H]-thymidine incorporation in human leukemic HL-60 cells was significantly reduced after incubation with agrostin showing that the RIP was inhibitory on the cell proliferation. Results from flow cytometric studies illustrated that apoptosis was induced by agrostin, which was associated with activation of endonucleases acid DNA fragmentation of the leukemic cells. Anti-apoptotic bcl-2 protein level was also reduced by agrostin showing that the associated apoptotic pathway might involve down-regulation of the intracellular bcl-2 protein level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:32