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Titolo:
Molecular cloning and characterization of human WNT8A
Autore:
Saitoh, T; Katoh, M;
Indirizzi:
Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Div Genet,Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 iv Genet,Chuo Ku, Tokyo 1040045, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 123 - 127
SICI:
1019-6439(200107)19:1<123:MCACOH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; XENOPUS EMBRYOS; GENE FAMILY; EXPRESSION; MUTATIONS; CANCER; CELLS; IDENTIFICATION; PATHWAY; MEMBER;
Keywords:
WNT; frizzled; NT2; gastric cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Div Genet,Chuo Ku, Tsukiji 5 Chome, Tokyo 1040045, Japan Natl Canc Ctr Tsukiji 5 Chome Tokyo Japan 1040045 1040045, Japan
Citazione:
T. Saitoh e M. Katoh, "Molecular cloning and characterization of human WNT8A", INT J ONCOL, 19(1), 2001, pp. 123-127

Abstract

WNT - beta -catenin - TCF pathway is involved in carcinogenesis and fetal development. Xenopus wnt-8 is one of the most potent Wnts with the capacityto activate beta -catenin - TCF pathway in the Xenopus axis duplication assay. Here, we have cloned and characterized WNT8A, a novel human homologue of Xenopus wnt-8.. The WNT8A gene, consisting of at least 6 exons, was found to encode a 351-amino-acid polypeptide with the N-terminal signal peptide, three N-linked glycosylation sites, and conserved amino-acid residues of the WNT family. WNT8A showed 63.2% total-amino-acid identity to WNTT8B. C-terminal region of WNT8A, WNT8B, WNT2, WNT2B1 and WNT2B2 were longer than that of other WNTs. Among various normal human tissues and 34 human cancer cells lines, the 3.5-kb WNT8A mRNA was detected only in a human teratocarcinoma cell line NT2. These results strongly suggest that WNT8A might be implicated in development of early embryos as well as germ cell tumors through activation of the WNT - beta -catenin - TCF pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:17:09