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Titolo:
Reduced expression of REIC/Dkk3 gene in non-small cell lung cancer
Autore:
Nozaki, I; Tsuji, T; Iijima, O; Ohmura, Y; Andou, A; Miyazaki, M; Shimizu, N; Namba, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Cell Biol, Inst Mol & Cellular Biol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Cellular Biol, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Surg 2, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 2, Okayama 7008558, Japan Hisamitsu Pharmaceut Co Inc, Cent Res Ctr, Tsukuba, Ibaraki 3050856, JapanHisamitsu Pharmaceut Co Inc Tsukuba Ibaraki Japan 3050856 3050856, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 117 - 121
SICI:
1019-6439(200107)19:1<117:REORGI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; HEPATOCELLULAR CARCINOMAS; WNT; MUTATIONS; FAMILY; DICKKOPF-1; INHIBITOR; PROTEINS; MOUSE; LINES;
Keywords:
Wnt; non-small cell lung cancer; real-time PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Namba, M Okayama Univ, Sch Med, Dept Cell Biol, Inst Mol & Cellular Biol, 2-5-1 Shikata, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Okayama Japan 7008558 7008558, Japan
Citazione:
I. Nozaki et al., "Reduced expression of REIC/Dkk3 gene in non-small cell lung cancer", INT J ONCOL, 19(1), 2001, pp. 117-121

Abstract

Dickkopfs (Dkks) are secretory glycoproteins and are important for inducing amphibian head formation. Some Dkks have the ability to antagonize the Wnt proto-oncoprotein, which can promote cell proliferation and transformation when it is mutated or overexpressed. We recently cloned the REIC/Dkk-3 gene, one of the Dkks, and found that expression of the gene was markedly decreased in many human immortalized and tumor-derived cell lines. To further investigate the function of the REIC/Dkk-3 gene ill vivo, the gene expression was quantified in 57 surgically-resected non-small cell lung cancer (NSCLC) tissues and their adjacent normal lung tissues by real-time quantitative PCR analysis based on TaqMan methodology. The REIC/Dkk-3 mRNA level was significantly lower in NSCLC tissues than in normal lung tissues. Reduced expression of REIC/Dkk-3 in NSCLC was observed in 36 (63%) of the 57 tumors. Reduced expression of REIC/Dkk-3 was frequently observed in poorly differentiated adenocarcinoma and squamous cell carcinoma. These results indicate that reduced expression of REIC/Dkk-3 may be correlated with rapid cell proliferation in human NSCLC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:13:54