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Titolo:
Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells
Autore:
De Ledinghen, V; Monvoisin, A; Neaud, V; Krisa, S; Payrastre, B; Bedin, C; Desmouliere, A; Bioulac-Sage, P; Rosenbaum, J;
Indirizzi:
Univ Bordeaux 2, INSERM E9917, Grp Rech Etud Foie, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 d Foie, F-33076 Bordeaux, France Univ Bordeaux 2, Grp Etud Subst Nat Interet Therapeut, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 rapeut, F-33076 Bordeaux, France CHU Purpan, INSERM U 326, F-31059 Toulouse, France CHU Purpan Toulouse France F-31059 NSERM U 326, F-31059 Toulouse, France
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 83 - 88
SICI:
1019-6439(200107)19:1<83:TAGPBH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC STELLATE CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; EPITHELIAL-CELLS; FACTOR-RECEPTOR; PLASMINOGEN-ACTIVATOR; TYROSINE KINASE; SMOOTH-MUSCLE; IN-VITRO; EXPRESSION; LINES;
Keywords:
polyphenol; invasion; hepatocyte growth factor; myofibroblast; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenbaum, J Univ Bordeaux 2, INSERM E9917, Grp Rech Etud Foie, 146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076
Citazione:
V. De Ledinghen et al., "Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells", INT J ONCOL, 19(1), 2001, pp. 83-88

Abstract

We have shown that liver myofibroblasts stimulate in vitro invasion of hepatocellular carcinoma cell lines through a hepatocyte growth facror/urokinase-dependent mechanism. Resveratrol, a grapevine-derived polyphenol, has been shown to inhibit cellular events associated with tumor initiation, promotion and progression. The aim of this study was to evaluate the effects of trans-resveratrol on invasion of the human hepatoma cell line HepG2. Cell invasion was assessed using a Boyden chamber assay. Activation of the HGF signal transduction pathways was evaluated by Western blot with phospho-specific antibodies. Urokinase expression was measured by RT-PCR and zymography. Trans-resveratrol decreased hepatocyte growth factor-induced cell scattering and invasion. It also decreased cell proliferation without evidence for cytotoxicity or apoptosis. Trans-resveratrol did not decrease the level of the hepatocyte growth factor receptor c-met and did not impede the hepatocyte growth factor-induced increase in c-met precursor synthesis. Moreover, trans-resveratrol did not decrease hepatocyte growth factor-induced c-met autophosphorylation, or Akt-1 or extracellular-regulated kinases-l and -2 activation. Finally, it did not decrease urokinase expression and did not block the catalytic activity of urokinase. In conclusion, our results demonstrate that trans-resveratrol decreases hepatocyte growth factor-induced HepG2 cell invasion by an as yet unidentified post-receptor mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:46:08