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Titolo:
Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer
Autore:
Zhang, H; Sun, XF;
Indirizzi:
Linkoping Univ, Inst Biomed & Surg, Dept Oncol, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 Oncol, S-58185 Linkoping, Sweden Linkoping Univ, Inst Biomed & Surg, Dept Dermatol, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 matol, S-58185 Linkoping, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 49 - 52
SICI:
1019-6439(200107)19:1<49:LOPEPP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
P27(KIP1) EXPRESSION; P53 OVEREXPRESSION; COLON-CANCER; SURVIVAL; ADENOCARCINOMA; CARCINOMAS; MUTATIONS; INHIBITOR; PROTEIN; GENE;
Keywords:
p27 expression; survival; Dukes' stage; tumor location; colorectal carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, XF Linkoping Univ, Inst Biomed & Surg, Dept Oncol, S-58185 Linkoping,Sweden Linkoping Univ Linkoping Sweden S-58185 -58185 Linkoping, Sweden
Citazione:
H. Zhang e X.F. Sun, "Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer", INT J ONCOL, 19(1), 2001, pp. 49-52

Abstract

p27 is a cyclin-dependent kinase inhibitor which regulates progression of cells from G1 into S phase in a cell cycle. Loss of the negative regulator may contribute to oncogenesis and tumor progression. The aim of this study was to examine p27 expression in normal mucosa, primary and metastatic tumors from patients with colorectal adenocarcinomas and to analyze associationof p27 with patient survival and clinicopathological variables. p27 expression was estimated by immunohistochemistry in 178 primary colorectal cancers, 34 lymph node metastases and 48 normal mucosa samples from patients withcolorectal adenocarcinoma. Associations of p27 with patient survival, clinicopathological characteristics and expression of p53, p73 and DCC were analyzed. Loss of p27 was found in 51% of primary tumors, 68% of metastases and 56% of normal samples. The intensity of p27 staining was similar in the matched primary tumor, metastasis and normal mucosa. In patients with Dukes'B or with proximal tumors, the loss of p27 predicted poorer prognosis (p=0.03 and p=0.05, respectively). However, there were no significant differences in the patients with other individual Dukes' stage or distal tumors. No relationships were found between p27 and patients' gender, age, tumor location, growth pattern and expression of p53, p73 and DCC (p >0.05). The data suggest that loss of p27 was associated with poor prognosis in patients with Dukes' B tumor or those with proximal tumor. p27 might be a useful markerto identify the more progressive tumors in these groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:08:55