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Titolo:
Divergent effects of an alpha(2)-adrenergic antagonist on lipolysis and thermogenesis: Interactions with a beta(3)-adrenergic agonist in rats
Autore:
Gomez-Ambrosi, J; Fruhbeck, G; Aguado, M; Milagro, FI; Margareto, J; Martinez, AJ;
Indirizzi:
Univ Navarra, Dept Physiol & Nutr, Pamplona 31008, Spain Univ Navarra Pamplona Spain 31008 Physiol & Nutr, Pamplona 31008, Spain Clin Univ Navarra, Dept Endocrinol, Pamplona 31008, Spain Clin Univ Navarra Pamplona Spain 31008 Endocrinol, Pamplona 31008, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 103 - 109
SICI:
1107-3756(200107)8:1<103:DEOAAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; FAT-CELL FUNCTION; UNCOUPLING PROTEINS; BETA-3-ADRENERGIC AGONISTS; DIFFERENTIAL REGULATION; ADRENERGIC-RECEPTOR; WHITE ADIPOCYTES; MESSENGER-RNA; LEPTIN; MICE;
Keywords:
trecadrine; yohimbine; beta(3)-adrenoceptor agonist; alpha(2)-adrenoceptor antagonist; lipolysis; thermogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, AJ Univ Navarra, Dept Physiol & Nutr, Pamplona 31008, Spain UnivNavarra Pamplona Spain 31008 tr, Pamplona 31008, Spain
Citazione:
J. Gomez-Ambrosi et al., "Divergent effects of an alpha(2)-adrenergic antagonist on lipolysis and thermogenesis: Interactions with a beta(3)-adrenergic agonist in rats", INT J MOL M, 8(1), 2001, pp. 103-109

Abstract

This study was undertaken in order to test the hypothesis that selective beta (3)-AR stimulation and simultaneous blockade of alpha (2)-AR would result in an increase of lipolysis and thermogenesis in rats. Incubation of isolated white adipocytes with the alpha (2)-AR antagonist yohimbine produced a concentration-dependent increase in glycerol release (P <0.001) for all assayed concentrations (10(-12)-10(-6) M) and potentiated the lipolytic effect of the beta (3)-AR agonist Trecadrine. However, in vivo administration of yohimbine produced a marked decrease in body temperature (1.3-1.5 degreesC, P <0.001) and blocked the thermogenic effect of Trecadrine when simultaneously administered. A similar response was observed for whole body oxygen consumption. Furthermore, yohimbine did not modify brown adipose tissue oxygen consumption, but blocked the beta (3)-AR-mediated increase triggered byTrecadrine. Brown adipose tissue UCP-2 and -3 mRNA expression was not changed by yohimbine. In conclusion, the present work indicates that in vitro alpha (2)-AR blockade by yohimbine potentiates the beta (3)-AR-mediated stimulation of lipolysis. On the other hand, in vivo alpha (2)-AR antagonism blocks the thermogenic effects mediated by beta (3)-AR stimulation, suggesting a possible interplay between the receptors.

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Documento generato il 22/01/20 alle ore 18:38:30