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Titolo:
Comparison of RANTES chemokine induction by Th1 cytokines in human astroglial cell lines
Autore:
Li, QQ; Bever, CT;
Indirizzi:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Neurol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Therapeut, Baltimore, MD 21201 USA VA Maryland Hlth Care Syst, Med Res Serv, Baltimore, MD 21201 USA VA Maryland Hlth Care Syst Baltimore MD USA 21201 Baltimore, MD 21201 USA VA Maryland Hlth Care Syst, Neurol Serv, Baltimore, MD 21201 USA VA Maryland Hlth Care Syst Baltimore MD USA 21201 Baltimore, MD 21201 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 95 - 101
SICI:
1107-3756(200107)8:1<95:CORCIB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MESSENGER-RNA EXPRESSION; NF-KAPPA-B; TRANSFORMING GROWTH FACTOR-BETA-1; TATA-BINDING PROTEIN; OVARIAN-CANCER CELLS; INTERFERON-GAMMA; GENE-EXPRESSION; FACTOR-ALPHA; MULTIPLE-SCLEROSIS;
Keywords:
IL-1 beta; IFN-gamma; TNF-alpha; RANTES; chemokine; astrocyte; glia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Li, QQ W Virginia Univ, Hlth Sci Ctr, Mary Babb Randolph Canc Ctr, Morgantown, WV26506 USA W Virginia Univ Morgantown WV USA 26506 r, Morgantown, WV26506 USA
Citazione:
Q.Q. Li e C.T. Bever, "Comparison of RANTES chemokine induction by Th1 cytokines in human astroglial cell lines", INT J MOL M, 8(1), 2001, pp. 95-101

Abstract

Multiple sclerosis (MS) is a primary inflammatory demyelinating disease ofthe human central nervous system, characterized by accumulation of mononuclear cells of hematogenous origin. RANTES is a C-C (beta)-chemokine family member with strong chemoattractant activity for lymphocytes and monocytes that are implicated in the pathogenesis of MS lesions. However, the cellularsources of RANTES message and the regulation of its secretion within diseased blain are poorly understood. Therefore, we carried out this study to compare the effect of Th1 cytokines on the induction of RANTES in different human astrocytic cell lines. IFN-gamma alone had little effect on RANTES production in both U-373MG and U-105MG cells, while TNF-alpha or IL-1 beta alone had differential effects in the two cell lines. Low levels of RANTES chemokine were detected in culture supernatants from U-372MG cells. By contrast, TNF-alpha or IL-1 beta dramatically increased RANTES secretion in U-105MG cells. Interestingly, different combination treatments of cells with the three cytokines synergistically induced RANTES release from both U-373MG and U-105MG cells. Consistent with these results, we found similar expressionpatterns for RANTES at the comparable steady-state mRNA levels in both cell lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:16:57