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Titolo:
Karyotype analysis of tumorigenic human bronchial epithelial cells transformed by chrysolite asbestos using chemically induced premature chromosome condensation technique
Autore:
Suzuki, M; Piao, CQ; Zhao, YL; Hei, TK;
Indirizzi:
Columbia Univ Coll Phys & Surg, Ctr Radiol Res, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 43 - 47
SICI:
1107-3756(200107)8:1<43:KAOTHB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER EMBRYO CELLS; INDUCED NEOPLASTIC TRANSFORMATION; HUMAN-MALIGNANT MESOTHELIOMA; SISTER CHROMATID EXCHANGE; ALPHA-PARTICLES; ABERRATIONS; FREQUENCY; WORKERS; FIBERS;
Keywords:
asbestos; tumorigenic human bronchial epithelial cells; premature chromosome condensation (PCC); Giemsa-trypsin banding (G-banding); karyotype analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, M Natl Inst Radiol Sci, Inst Space Radiat Lab, Inage Ku, 4-9-1 Anagawa, Chiba 2638555, Japan Natl Inst Radiol Sci 4-9-1 Anagawa Chiba Japan 2638555 5, Japan
Citazione:
M. Suzuki et al., "Karyotype analysis of tumorigenic human bronchial epithelial cells transformed by chrysolite asbestos using chemically induced premature chromosome condensation technique", INT J MOL M, 8(1), 2001, pp. 43-47

Abstract

We examined karyotypic changes of tumorigenic human bronchial epithelial cell lines transformed by asbestos fibers. Using Calyculin A mediated premature chromosome condensation (PCC) assay and Giemsa-trypsin banding, we showed that the common changes of all tumorigenic cell lines were the loss of one or two copies of chromosome 5, the monosomy of chromosome 19 and the increased trisomy of chromosome 8. The results indicate that the karyotypic change of chromosome 5, 8 and 19 could play an important role in asbestos-induced tumorigenic conversion of human bronchial epithelial cells from an immortalized to tumorigenic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:59:20