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Titolo:
Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review)
Autore:
Wu, JM; Wang, ZR; Hsieh, TC; Bruder, JL; Zou, JG; Huang, YZ;
Indirizzi:
New York Med Coll, Dept Biochem & Mol Biol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 Mol Biol, Valhalla, NY 10595 USA Nanjing Med Univ, Nanjing, Peoples R China Nanjing Med Univ Nanjing Peoples R China Univ, Nanjing, Peoples R China
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 3 - 17
SICI:
1107-3756(200107)8:1<3:MOCBRA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; MODERATE ALCOHOL-CONSUMPTION; INHIBITS CYCLOOXYGENASE-2 TRANSCRIPTION; CANCER CHEMOPREVENTIVE ACTIVITY; NATURAL POLYPHENOLIC COMPOUND; ARACHIDONIC-ACID METABOLISM; HUMAN PLATELET-AGGREGATION; MAMMARY EPITHELIAL-CELLS; NITRIC-OXIDE SYNTHASE;
Keywords:
the French paradox; resveratrol; red wine; ischemia/reperfusion injury; atherosclerosis; LDL oxidation; platelet aggregation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
185
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, JM New York Med Coll, Dept Biochem & Mol Biol, Room 147,Basic Sci Bldg, Valhalla, NY 10595 USA New York Med Coll Room 147,Basic Sci Bldg ValhallaNY USA 10595 USA
Citazione:
J.M. Wu et al., "Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review)", INT J MOL M, 8(1), 2001, pp. 3-17

Abstract

Coronary heart disease (CHD) has been and remains a major contributor to morbidity and mortality in developed countries. The most common form of CHD in the western world is atherosclerosis (AS), especially of the major coronary arteries. Failure to maintain an intact endothelium, as a result of episodic and/or persistent injury and perturbation of the vascular endothelium, promotes formation of fatty streaks which are considered initiation events of AS. Cellular constituents contributing to endothelial injury include endothelial cells, monocytes, platelets, and smooth muscle cells. Individuals diagnosed with AS face complex, enduring clinical complications and enormous medical costs. Simple and easily compliant prevention and treatment measures are therefore strategic considerations in the management of this vascular disease. Based on known risk factors for CHD, priorities in AS prevention should include smoking cessation, blood pressure control, and diet modification. In recent years, the possible benefits of low to moderate consumption of alcoholic beverages, particularly of red wine, in the prevention ofheart disease has received increasing attention and debate in the popular media as well as in the scientific community. Such attention has been prompted by research findings supporting a relationship between red wine consumption and the French paradox. This phenomenon refers to people residing in certain parts of France where red wine is customarily consumed during meals having a low CHD mortality, despite living a lifestyle considered to have comparably high CHD risks, as those in the US and many other developed countries. Studies have reported that the cardioprotective effects of red wine are greater than those attributed solely to ethanol and other types of alcoholic beverages. The mechanism(s) underlying the greater CHD protective benefits of red wine have not been elucidated. Recently the polyphenol resveratrol (3,5,4'-trihydroxy-trans-stilbene), known to be abundantly present: in red wine, compared to white wine, beer, or spirits, has been demonstrated to elicit a broad spectrum of biological responses in in vitro and in animalstudies, including effects that are compatible with the cardioprotective roles proposed for red wine. These recently described effects of resveratrolwill be reviewed in this article. We will first summarize published data showing an inverse association between consumption of alcoholic beverages/red wine and risk of CHD. A review of biosynthesis of resveratrol and its presence in food groups and wines will follow. Recent studies relating exposure to wine/resveratrol with reduction in myocardial damage during ischemia-reperfusion, modulation of vascular cell functions, inhibition of LDL oxidation, and suppression of platelet aggregation will be presented. The last section of this review will focus on a discussion of mechanism(s) by which resveratrol acts as a potential cardioprotective agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:40:02