Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
New clinical applications of xanthine derivatives: Modulatory actions on leukocyte survival and function
Autore:
Yasui, K; Komiyama, A;
Indirizzi:
Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 73, anno: 2001,
pagine: 87 - 92
SICI:
0925-5710(200101)73:1<87:NCAOXD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; HUMAN EOSINOPHIL FUNCTIONS; ADENOSINE A(2B) RECEPTORS; HUMAN-NEUTROPHILS; CYCLIC-AMP; PHOSPHODIESTERASE INHIBITION; ANTIINFLAMMATORY MECHANISM; MARROW TRANSPLANTATION; GRANULOCYTE APOPTOSIS; INHALED BUDESONIDE;
Keywords:
theophylline; xanthine analogues; adenosine; phosphodiesterase; granulocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Yasui, K Shinshu Univ, Sch Med, Dept Pediat, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan Shinshu Univ Asahi 3-1-1 Matsumoto Nagano Japan 3908621 21, Japan
Citazione:
K. Yasui e A. Komiyama, "New clinical applications of xanthine derivatives: Modulatory actions on leukocyte survival and function", INT J HEMAT, 73(1), 2001, pp. 87-92

Abstract

The use of theophylline in the treatment of obstructive pulmonary diseaseshas diminished with the advent of new medications. However. its use as a second-line bronchodilator has been reconsidered in recent years. Theophylline is reported to have immunomodulatory actions that may account for its clinical effectiveness in the control of airway inflammation. Theophylline, even at low plasma concentrations, inhibits the late asthmatic reaction following allergen challenge. The apparent suppression of airway inflammation by theophylline reinforces findings from in vitro experiments (including ourrecent studies). Its immunomodulatory actions include inhibition of cytokine synthesis and release, inhibition of inflammatory cell activation, and acceleration of granulocyte apoptosis. On the basis of these findings, theophylline has been re-evaluated as a key drug for the long-term management ofbronchial asthma, and new applications are proposed for the clinical use of xanthine derivatives. Here, we review some recent advances in the understanding of pharmacological actions and new applications of xanthine derivatives. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:37:34