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Titolo:
Zebrafish - An emerging genetic model for the study of cytokines and hematopoiesis in the era of functional genomics
Autore:
Lieschke, GJ;
Indirizzi:
Royal Melbourne Hosp, Ludwig Inst Canc Res, Melbourne Tumour Biol Branch, Cytokine Biol Lab, Melbourne, Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 ne, Vic 3050, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 73, anno: 2001,
pagine: 23 - 31
SICI:
0925-5710(200101)73:1<23:Z-AEGM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT ONCORHYNCHUS-MYKISS; DANIO-RERIO; TRANSGENIC ZEBRAFISH; POSITIONAL CLONING; MOLECULAR-CLONING; CELL-MIGRATION; EXPRESSION; IDENTIFICATION; CLOCHE; INTERLEUKIN-1-BETA;
Keywords:
zebrafish; mutagenesis; hematopoiesis; blood; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Lieschke, GJ Royal Melbourne Hosp, Ludwig Inst Canc Res, Melbourne Tumour Biol Branch, Cytokine Biol Lab, POB 2008, Melbourne, Vic 3050, Australia Royal Melbourne Hosp POB 2008 Melbourne Vic Australia 3050 ia
Citazione:
G.J. Lieschke, "Zebrafish - An emerging genetic model for the study of cytokines and hematopoiesis in the era of functional genomics", INT J HEMAT, 73(1), 2001, pp. 23-31

Abstract

Now that whole genomes are sequenced, the identification of gene function rather than gene discovery is a major challenge. Saturation mutagenesis andscreening for mutant phenotypes are methods that allow sampling of the genome for lesions in genes crit ical for particular physiological processes. This approach promises to provide new insights into gene function, even formolecularly well-characterized processes such as hematopoiesis and cytokine signaling. Animal models for such genetic approaches have traditionally included Drosophila and the mouse. Recently, the zebrafish (Danio rerio) hasemerged as a flexible and informative vertebrate for genetic studies. Zebrafish hematopoiesis has a morphological and molecular complexity closer to that of mammals than does Drosophila, providing scope for recognizing mutant zebrafish phenotypes representing finely tuned lesions in these processes, Compared to mice, zebrafish represent an economical, flexible, and genetically tractable animal model for mutagenesis studies. The structure of the teleost genome creates several phylogenetic issues in assessing zebrafish and piscine orthologues and paralogues of known mammalian genes, here exemplified by a cytokine ligand (interleukin-l beta), kinase receptors (c-kit and c-fms), and a family of intracellular signaling molecules (JAK kinases). Several anemic zebrafish mutants are now genetically characterized, and others present hematopoietic phenotypes that promise novel insights into the regulation of hematopoiesis. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 08:35:35