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Titolo:
A Hodgkin's disease cell line, KM-H2, shows biphenotypic features of dendritic cells and B cells
Autore:
Uehira, K; Amakawa, R; Ito, T; Uehira, T; Ozaki, Y; Shimizu, T; Fujimoto, M; Inaba, M; Fukuhara, S;
Indirizzi:
Kansai Med Univ, Dept Internal Med 1, Moriguchi, Osaka 5708507, Japan Kansai Med Univ Moriguchi Osaka Japan 5708507 guchi, Osaka 5708507, Japan Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 5708507, Japan Kansai MedUniv Moriguchi Osaka Japan 5708507 guchi, Osaka 5708507, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 2, volume: 73, anno: 2001,
pagine: 236 - 244
SICI:
0925-5710(200102)73:2<236:AHDCLK>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REED-STERNBERG CELLS; TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; ACTIN-BUNDLING PROTEIN; MIXED CELLULARITY; LANGERHANS CELLS; EXPRESS CD83; BONE-MARROW; ANTIGEN; ORIGIN;
Keywords:
KM-HZ cell line; Hodgkin's disease; Reed-Sternberg cells; dendritic cells; fascin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Amakawa, R Kansai Med Univ, Dept Internal Med 1, 10-15 Fumizono Cho, Moriguchi, Osaka5708507, Japan Kansai Med Univ 10-15 Fumizono Cho Moriguchi Osaka Japan 5708507
Citazione:
K. Uehira et al., "A Hodgkin's disease cell line, KM-H2, shows biphenotypic features of dendritic cells and B cells", INT J HEMAT, 73(2), 2001, pp. 236-244

Abstract

The origin of Reed-Sternberg (RS) cells, the neoplastic cells of Hodgkin'sdisease, has long remained controversial. Dendritic cells (DCs) are highlyspecialized antigen-presenting cells that have the unique capacity to prime naive T cells, and they may be progenitors of RS cells in a population ofHodgkin's disease cells. In this study, the KM-H2 cell line, previously established from a patient with Hodgkin's disease of mixed cellularity, was reevaluated for its cellular derivation, particularly in terms of DCs. KM-H2cells were demonstrated to carry the newly proposed DC-associated molecules fascin, CD83, and DEC-205, as well as costimulatory molecules such as CD40, CD80, and CD86. In addition. KM-H2 cells were shown to be able to potently stimulate peripheral blood T cells and to have the strong endocytotic activity of fluorescein isothiocyanate-dextran. On the other hand. KM-H2 cells were shown to have variable-diversity-joining recombination of the immunoglobulin H gene, although they did not express any subclasses of immunoglobulin and they were negative for CD79a and CD79b. In addition, KM-H2 cells produced the messenger RNA of the Pax-5 gene. These findings lead to a hypothesis that KM-H2 cells originated from the cells that had differentiated through the possible common DC-B-cell progenitors along the newly proposed pathway. (C) 2001 The Japanese Society of Hematology.

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Documento generato il 30/05/20 alle ore 15:21:35