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Titolo:
Pathogenesis of thrombosis in patients with malignancy
Autore:
Falanga, A; Donati, MB;
Indirizzi:
Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Vasc Med & Pharmacol, I-66030 Santa Maria Imbaro, Italy Ist Ric Farmacol Mario Negri Santa Maria Imbaro Italy I-66030 aro, Italy Osped Riuniti Bergamo, Div Hematol, I-24100 Bergamo, Italy Osped Riuniti Bergamo Bergamo Italy I-24100 atol, I-24100 Bergamo, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 2, volume: 73, anno: 2001,
pagine: 137 - 144
SICI:
0925-5710(200102)73:2<137:POTIPW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-RETINOIC ACID; ACUTE PROMYELOCYTIC LEUKEMIA; BONE-MARROW TRANSPLANTATION; CELL-LINE NB4; LOW-DOSE WARFARIN; CANCER PROCOAGULANT; TISSUE-FACTOR; ENDOTHELIAL-CELL; BREAST-CANCER; STANDARDIZATION COMMITTEE;
Keywords:
thrombosis; cancer; metastasis; tumor procoagulants; cancer chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Donati, MB Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Vasc Med & Pharmacol, Via Nazl, I-66030 Santa Maria Imbaro, Italy Ist Ric Farmacol Mario Negri Via Nazl Santa Maria Imbaro Italy I-66030
Citazione:
A. Falanga e M.B. Donati, "Pathogenesis of thrombosis in patients with malignancy", INT J HEMAT, 73(2), 2001, pp. 137-144

Abstract

Cancer cells can contribute to activation of the clotting system by their capacity to produce and release procoagulant/fibrinolytic substances and inflammatory cytokines, and by their interaction with host cells (endothelial, monocytes, platelets, and neutrophils). Moreover, anticancer drugs (chemotherapy/hormone therapy) may greatly affect the risk of thromboembolic complications in cancer patients by similar mechanisms, eg, through the releaseof procoagulants by tumor cells, through endothelial damage, or stimulation of tissue factor production by host cells. The interactions between cancer/metastatic processes and thrombosis have been reviewed here from the pathogenetic viewpoint. We hope that better knowledge of these pathogenetic pathways will lead to the development of more targeted strategies to prevent thromboembolism in cancer patients. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:13:27