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Titolo:
Immunohistochemical expression of gastric mucin and p53 in minimal deviation adenocarcinoma of the uterine cervix
Autore:
Ichimura, T; Koizumi, T; Tateiwa, H; Yamaguchi, S; Takemori, M; Hasegawa, K; Nishimura, R;
Indirizzi:
Hyogo Inst Clin Res, Kobe, Hyogo 6738558, Japan Hyogo Inst Clin Res Kobe Hyogo Japan 6738558 , Kobe, Hyogo 6738558, Japan Hyogo Med Ctr Adults, Dept Obstet & Gynecol, Akashi, Hyogo, Japan Hyogo Med Ctr Adults Akashi Hyogo Japan & Gynecol, Akashi, Hyogo, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 220 - 226
SICI:
0277-1691(200107)20:3<220:IEOGMA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMA MALIGNUM; MONOCLONAL-ANTIBODY; CARCINOMA; DIFFERENTIATION; DIAGNOSIS; LESIONS; BREAST; KI-67;
Keywords:
uterine cervix; minimal deviation adenocarcinoma; adenoma malignum; p53; gastric mucin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, R Hyogo Inst Clin Res, 13-70 Kitaoji Cho, Kobe, Hyogo 6738558, Japan Hyogo Inst Clin Res 13-70 Kitaoji Cho Kobe Hyogo Japan 6738558
Citazione:
T. Ichimura et al., "Immunohistochemical expression of gastric mucin and p53 in minimal deviation adenocarcinoma of the uterine cervix", INT J GYN P, 20(3), 2001, pp. 220-226

Abstract

Comparative immunostaining with antibodies against gastric mucin and p53 was performed on 6 cases of minimal deviation adenocarcinoma (MDA) of the uterine cervix. The MDAs consisted of predominant areas of glands lined by extremely well-differentiated tall columnar epithelial cells with little cytological atypia and minor foci of less well-differentiated glandular epithelium with a minor degree of nuclear atypia. Immunostaining for gastric mucinwith a monoclonal antibody HIK1083 revealed that all the tumors areas of typical MDA were partly immunoreactive fur HIK1083, but the coexisting less well-differentiated glands were essentially negative. Four MDAs focally contained cells with p53 positive nuclei that were located exclusively in the less well-differentiated cells that lacked gastric mucin. In the pelvic lymph nodes in 2 cases, most of the metastatic tumor was less differentiated and a positive reaction for HIK1083 was observed only in small foci of typical MDA. No significant overexpression of p53 was observed in the metastases. Immunohistochemical expression of gastric mucin and p53 may be related tothe histological differentiation of MDA, and detection of p53 overexpression may help to identify critical steps in the local progression of MDA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:09:10