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Titolo:
Substance P
Autore:
Harrison, S; Geppetti, P;
Indirizzi:
Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 harmacol Sect, I-44100 Ferrara, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 6, volume: 33, anno: 2001,
pagine: 555 - 576
SICI:
1357-2725(200106)33:6<555:SP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; TACHYKININ NK1 RECEPTOR; DORSAL-ROOT-GANGLIA; RAT SPINAL-CORD; SENSITIVE SENSORY NERVES; HAMSTER OVARY CELLS; GUINEA-PIG ILEUM; VASOACTIVE INTESTINAL POLYPEPTIDE; ANGIOTENSIN CONVERTING ENZYME; PLASMA-PROTEIN EXTRAVASATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
253
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, S Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, Via Fossato Di Mortara19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Di Mortara 19 Ferrara Italy I-44100
Citazione:
S. Harrison e P. Geppetti, "Substance P", INT J BIO C, 33(6), 2001, pp. 555-576

Abstract

This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substanceP receptor agonists and antagonists, and mon recently the employment of transgenic mice, provide a framework to explore the functional role of substance P. Chronic inflammation and pain are associated with a number of diseases, and it has been proposed that substance P, released from primary afferent nerve endings play a role in these conditions. Recent developments with substance P antagonists have demonstrated the importance of substance P in several models of disease that span from asthma to chronic bronchitis; fromcystitis, inflammatory bowel disease to migraine; emesis, depression, painand seizures. Advancements in the knowledge of the role of substance P, its agonists and antagonists could provide clinical solutions for a variety of chronic inflammatory conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:35:31