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Titolo:
CD40-ligand in primate cardiac allograft and viral immunity
Autore:
Pierson, RN; Crowe, JE; Pfeiffer, S; Atkinson, J; Azimzadeh, A; Miller, GG;
Indirizzi:
Vanderbilt Univ, Med Ctr, Nashville, TN USA Vanderbilt Univ Nashville TN USA erbilt Univ, Med Ctr, Nashville, TN USA VAMC, Dept Cardiothorac Surg, Nashville, TN USA VAMC Nashville TN USAVAMC, Dept Cardiothorac Surg, Nashville, TN USA VAMC, Dept Pediat, Nashville, TN USA VAMC Nashville TN USAVAMC, Dept Pediat, Nashville, TN USA VAMC, Dept Med, Nashville, TN USA VAMC Nashville TN USAVAMC, Dept Med, Nashville, TN USA VAMC, Dept Pathol, Nashville, TN USA VAMC Nashville TN USAVAMC, Dept Pathol, Nashville, TN USA
Titolo Testata:
IMMUNOLOGIC RESEARCH
fascicolo: 2-3, volume: 23, anno: 2001,
pagine: 253 - 262
SICI:
0257-277X(2001)23:2-3<253:CIPCAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; CD40 CROSS-LINKING; TRANSPLANTATION TOLERANCE; HEMATOPOIETIC CHIMERISM; ANTIBODY-PRODUCTION; NONHUMAN-PRIMATES; ANTI-CD40 LIGAND; MIXED CHIMERISM; B-CELLS; INDUCTION;
Keywords:
CD40L; CD154; costimulation; allograft; heart; cardiac; influenza virus; transplant; nonhuman primate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Pierson, RN 2986 Vanderbilt Clin, Nashville, TN 37232 USA 2986 Vanderbilt Clin Nashville TN USA 37232 lle, TN 37232 USA
Citazione:
R.N. Pierson et al., "CD40-ligand in primate cardiac allograft and viral immunity", IMMUNOL RES, 23(2-3), 2001, pp. 253-262

Abstract

Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find thatintensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in association with rising antidonor antibody titers and allograft vasculopathy, despite continuing anti-CD40L therapy. In contrast, the primary humoral response to T helper dependent influenza viral antigen is inhibited during anti-CD40L therapy, and responses to subsequent immunization are blunted after discontinuation of therapy. These results are encouraging with regard to the tolerogenic potential of costimulatory blockade for specific T helper dependent antigens. However, these findings also indicate that pathogenic allograft responses in primates are probably not entirely CD40L-dependent. As such, additional immunomodulatory strategies are needed to facilitate tolerance to a transplanted organ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:48:30