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Titolo:
A comparison between systolic and diastolic pulse contour analysis in the evaluation of arterial stiffness
Autore:
Rietzschel, ER; Boeykens, E; De Buyzere, ML; Duprez, DA; Clement, DL;
Indirizzi:
State Univ Ghent Hosp, Dept Cardiol & Angiol, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 Angiol, B-9000 Ghent, Belgium
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 37, anno: 2001,
pagine: E15 - E22
SICI:
0194-911X(200106)37:6<E15:ACBSAD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
AORTIC BLOOD-PRESSURE; GENERALIZED TRANSFER-FUNCTIONS; APPLANATION TONOMETRY; AUGMENTATION INDEX; WAVE ANALYSIS; BODY HEIGHT; HYPERTENSION; ACCURACY; DISEASE; REPRODUCIBILITY;
Keywords:
arteries; pulsatile flow; wave reflections; Windkessel model; hypertension, diagnosis; reproducibility of results;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Rietzschel, ER State Univ Ghent Hosp, Dept Cardiol & Angiol, De Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp De Pintelaan 185 Ghent Belgium B-9000
Citazione:
E.R. Rietzschel et al., "A comparison between systolic and diastolic pulse contour analysis in the evaluation of arterial stiffness", HYPERTENSIO, 37(6), 2001, pp. E15-E22

Abstract

Several methodologically independent measures of arterial stiffness derived from either the systolic or diastolic segments of the arterial pulse havebeen proposed. The exact nature of the large and small artery elasticity indices (C1 and C2, respectively) derived from diastolic pulse contour analysis remains largely unexplored, although C2 has controversially been termedto be "oscillatory" and "reflective. " We investigated the relation betweenC2 and, respectively, a prototype of arterial reflectivity (ie, the augmentation index, AIx) and a covariate of arterial reflectivity (body height). A validated transfer function is used to transform a tonometrically obtained radial pressure wave into an ascending aortic pressure wave, from which AIx is derived using systolic pulse contour analysis. Diastolic pulse contour analysis using a modified Windkessel model is used to derive C1 and C2. One hundred subjects, who were free from atherothrombotic disease and 19 to 77 years of age, with a wide pressure range (97 to 186/52 to 104 mm Hg) were studied. Mean values of C1, C2, AIx, and body height were, respectively, 13.8 +/-4.3 mL/mmHgX10, 5.9 +/-3.1 mL/mm HgX 100, 128.5 +/- 24.9%, and 169 /-9 cm. Coefficients of variation were 32.8% for C1, 33.3% for C2, and 6.7% for AIx. C2 was significantly and inversely correlated to AIx (r=-0.707, P <0.001). Both AIx and C2 were correlated to body height (r=-0.487, P<0.001, and r=0.514, P<0.001). In conclusion, the results of this study provide the first clinical evidence that validates a probable biophysical equivalent of the C2 element of a third-order, 4-element modified Windkessel model. We suggest that C2 is, at least in part, a measure of arterial wave reflectance. However, although short-term reproducibility of AIx is excellent, C2 showed markedly increased variability with the devices used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:04:59