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Titolo:
Impaired insulin-like growth factor I vasorelaxant effects in hypertension
Autore:
Vecchione, C; Colella, S; Fratta, L; Gentile, MT; Selvetella, G; Frati, G; Trimarco, B; Lembo, G;
Indirizzi:
IRCCS INM Neuromed, I-86077 Pozzilli, IS, Italy IRCCS INM Neuromed Pozzilli IS Italy I-86077 I-86077 Pozzilli, IS, Italy Univ Naples Federico II, Sch Med, Dept Internal Med, Naples, Italy Univ Naples Federico II Naples Italy , Dept Internal Med, Naples, Italy Univ La Sapienza, Dept Expt Med & Pathol, Rome, Italy Univ La Sapienza Rome Italy pienza, Dept Expt Med & Pathol, Rome, Italy
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 37, anno: 2001,
pagine: 1480 - 1485
SICI:
0194-911X(200106)37:6<1480:IIGFIV>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; VASCULAR SMOOTH-MUSCLE; MESSENGER-RNA LEVELS; NITRIC-OXIDE; RAT AORTA; SYMPATHETIC VASOCONSTRICTION; GENE-EXPRESSION; BLOOD-PRESSURE; RECEPTOR; ACTIVATION;
Keywords:
vascular reactivity; aorta; norepinephrine; nitric oxide; receptors, adrenergic, alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lembo, G IRCCS INM Neuromed, Localita Camerelle, I-86077 Pozzilli, IS, Italy IRCCS INM Neuromed Localita Camerelle Pozzilli IS Italy I-86077 y
Citazione:
C. Vecchione et al., "Impaired insulin-like growth factor I vasorelaxant effects in hypertension", HYPERTENSIO, 37(6), 2001, pp. 1480-1485

Abstract

Insulin-like growth factor I (IGF-I) can be considered a factor potentially involved in arterial hypertension not only for its,growth-promoting features but also for its effects on vascular tone. Nevertheless, the actions ofthe hormone on vascular reactivity are still unexplored in hypertension. Therefore, the vasodilation induced by increasing doses of IGF-I and the modulation of norepinephrine vasoconstriction induced by low levels of the hormone were tested on aortic rings of spontaneously hypertensive and normotensive rats. The results indicate that the vasodilation evoked by IGF-I is impaired in hypertensive rats (Delta% of maximal vasorelaxation, 30 +/-1 versus 41 +/-1; P <0.01), and after the removal of endothelium or the inhibition of endothelial NO synthase, the vasodilation evoked by the hormone was blunted in both rat strains and became similar between hypertensive and normotensive rats (Delta% of maximal vasorelaxadon, 21 +/-1 versus 20 +/-1; P=NS). Moreover, IGF-I does not show any effect on norepinephrine vasoconstriction in hypertensive rats, and this alteration may depend on the lack of sensitizing effect exerted by IGF-I on alpha (2)-adrenergic-evoked NO vasorelaxation. The defect in IGF-I vascular action is also present in young spontaneously hypertensive rats (age 5 weeks). In conclusion, our data demonstrate that IGF-I vasorelaxant properties are impaired in spontaneously hypertensive rats, suggesting that such defect may play a causative or permissive role in the development of hypertensive conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:31:38