Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Normal blood pressure and renal function in mice lacking the bradykinin B-2 receptor
Autore:
Milia, AF; Gross, V; Plehm, R; De Silva, JA; Bader, M; Luft, FC;
Indirizzi:
Franz Volhard Clin, D-13122 Berlin, Germany Franz Volhard Clin Berlin Germany D-13122 Clin, D-13122 Berlin, Germany Humboldt Univ, Charite, Fac Med, Max Delbruck Ctr Mol Med, Berlin, GermanyHumboldt Univ Berlin Germany Max Delbruck Ctr Mol Med, Berlin, Germany Natl Inst Biostruct & Biosyst, Osilo, Italy Natl Inst Biostruct & BiosystOsilo Italy truct & Biosyst, Osilo, Italy
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 37, anno: 2001,
pagine: 1473 - 1479
SICI:
0194-911X(200106)37:6<1473:NBPARF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
II TYPE-2 RECEPTOR; ARTERIAL-PRESSURE; CARDIOVASCULAR PHENOTYPE; AT(2) RECEPTOR; KNOCKOUT MICE; HEART-RATE; SALT; NATRIURESIS; HYPERTENSION; KININS;
Keywords:
bradykinin; mice; natriuresis; kidney; sodium, dietary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Luft, FC Franz Volhard Clin, Wiltberg Str 50, D-13122 Berlin, Germany Franz Volhard Clin Wiltberg Str 50 Berlin Germany D-13122 ermany
Citazione:
A.F. Milia et al., "Normal blood pressure and renal function in mice lacking the bradykinin B-2 receptor", HYPERTENSIO, 37(6), 2001, pp. 1473-1479

Abstract

Telemetric blood pressure determinations, heart rate measurements, and pressure-natriuresis-diuresis experiments were used to characterize cardiovascular and renal function in bradykinin B-2 receptor knockout mice fed mouse chow containing 0.25% NaCl or mouse chow containing 4% NaCl. In B, receptorknockout mice fed usual mouse chow, the mean arterial blood pressure leveled between 108 +/-1 and 110 +/-3 mm Hg, and the heart rate leveled between 520 +/- 26 and 525 +/- 29 bpm, values that were not different from those measured in B-2 receptor knockout mice or 129Sv/J control mice. Increasing dietary salt intake did not affect mean arterial blood pressure and heart rate. Accordingly, pressure-natriuresis curves, pressure-diuresis curves, renal blood flow, and glomerular filtration rate were not different between B-2receptor knockout and 129Sv/J mice. Increasing dietary salt intake to 4% increased renal blood flow to levels between 8.41 and 9.50 mL/min per gram kidney wet weight in 129Sv/J mice, whereas in B-2 receptor-deficient mice, renal blood flow was not affected and ranged between 6.85 and 7.88 mL/min per gram kidney wet weight. Other renal function parameters were not affected. Absence of B-2 receptor function was verified in B, receptor knockout mice with bradykinin infusion. These data suggest that the absence of B-2 receptor function does not necessarily make B-2 receptor knockout mice hypertensive or induce salt sensitivity. Presumably, differences in the genetic background or an adaptation to the loss of B-2 receptor function may account for these results, in contrast with earlier reports involving B-2 receptor knockout mice, We hold the latter possibility to be more likely and to be a fruitful possibility for future research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:21:05