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Titolo:
Autonomic function in hypertensive and normotensive subjects - The importance of gender
Autore:
Sevre, K; Lefrandt, JD; Nordby, G; Os, I; Mulder, M; Gans, ROB; Rostrup, M; Smit, AJ;
Indirizzi:
Ulleval Univ Hosp, Dept Cardiol, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 , Dept Cardiol, N-0407 Oslo, Norway Ulleval Univ Hosp, Dept Internal Med, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 t Internal Med, N-0407 Oslo, Norway Ulleval Univ Hosp, Res Forum, N-0407 Oslo, Norway Ulleval Univ Hosp OsloNorway N-0407 osp, Res Forum, N-0407 Oslo, Norway Univ Groningen Hosp, Dept Internal Med, NL-9713 EZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 EZ ningen, Netherlands
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 37, anno: 2001,
pagine: 1351 - 1356
SICI:
0194-911X(200106)37:6<1351:AFIHAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; COLD PRESSOR TEST; BAROREFLEX SENSITIVITY; MYOCARDIAL-INFARCTION; REFLEX SENSITIVITY; SPECTRAL-ANALYSIS; WOMEN; MORTALITY; ARTERY; AGE;
Keywords:
hypertension; gender; baroreflex; catecholamines; heart rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sevre, K Ulleval Univ Hosp, Dept Cardiol, N-0407 Oslo, Norway Ulleval UnivHosp Oslo Norway N-0407 rdiol, N-0407 Oslo, Norway
Citazione:
K. Sevre et al., "Autonomic function in hypertensive and normotensive subjects - The importance of gender", HYPERTENSIO, 37(6), 2001, pp. 1351-1356

Abstract

Baroreceptor reflex sensitivity (BRS) has been found lower and heart rate variability (HRV) parasympathetic markers have been found higher in healthywomen than in healthy men. Thus, in the present study we hypothesized gender differences in the autonomic function among hypertensive subjects. Forty-one hypertensive patients and 34 normotensive subjects, age 53 +/-1 years,were examined. Four weeks after cessation of antihypertensive therapy, HRVwas assessed in 24-hour Holter ECGs, and BRS was calculated with the transfer technique. A t test was performed after log transformation of spectral values. Resting blood pressure and heart rate in the hypertensive and the normotensive groups were 150 +/-2/100 +/-1 (mean +/- SEM) and 121 +/-2/81 +/-1 mmHg, respectively, and 68 +/-1 and 60 +/-1 bpm, respectively (P <0.0005). Compared with normotensive controls, hypertensive patients had lower total power (1224 +/- 116 versus 1797 +/- 241 ms(2); P=0.03), lower low frequency power (550 +/- 57 versus 813 +/- 115 ms(2); P=0.04), lower high frequency power (141 +/- 23 versus 215 +/- 38 ms(2); P=0.06), lower root mean square successive difference (28.7 +/-2.7 versus 35.7 +/-3.0 ms; P=0.03), and PNN5O (4.9 +/-0.6% versus 9.8 +/-1.5%; P=0.003). BRS was also lower in the hypertensive subjects (7.6 +/-0.6 versus 10.4 +/-0.8 ms/mm Hg; P=0.005). When comparing the same parameters between normotensive subjects and hypertensive subjects within the same gender group, we found significant reduction (P <0.05) only within the female group. The difference in BRS within the female group was twice that within the male group. Stepwise multiple regression analysis revealed gender, age, HDL cholesterol, and blood pressure as independent explanatory variables of BRS and HRV. Our results suggest that gender is an important determinant of BRS and HRV. Autonomic function parameters were especially impaired in hypertensive women compared with hypertensive men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:29:02